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• W2997678088 abstract "Background and objective For many pathological states, microparticles are supposed to be one of the causes of hypercoagulation. Although there are some indirect data about microparticles participation in coagulation activation and propagation, the integral hemostasis test Thrombodynamics allows to measure micropaticles participation in these two coagulation phases directly by influence on the appearance of coagulation centers in plasma volume and on the rate of clot grown from surface with immobilized tissue factor. Methods Microparticles were obtained from platelets and erythrocytes by stimulation with SFLLRN and A23187, respectively, from monocytes, endothelial HUVEC culture and monocytic THP cell culture by stimulation with lipopolysaccharides. Microparticles were counted by flow cytometry and titrated in microparticle-depleted normal plasma in the Thrombodynamics test. Results Monocyte microparticles induced the appearance of clotting centres through the TF pathway at concentrations approximately 100-fold lower than platelet and erythrocyte microparticles, which activated plasma by the contact pathway. For endothelial microparticles, both activation pathways were essential, and their activity was intermediate. Monocyte microparticles induced plasma clotting by the appearance of hundreds of clots with an extremely slow growth rate, while erythrocyte microparticles induced the appearance of a few clots with a growth rate similar to that from surface covered with high-density tissue factor. Patterns of clotting induced by platelet and endothelial microparticles were intermediate. Platelet, erythrocyte and endothelial microparticles impacts on the rate of clot growth from the surface with tissue factor did not differ significantly within the 0-200·10 3 /ul range of microparticles concentrations. However, at concentrations greater than 500·10 3 /ul, erythrocyte microparticles increased the stationary clot growth rate to significantly higher levels than do platelet microparticles or artificial phospholipid vesicles consisting of phosphatidylcholine and phosphatidylserine. Conclusion Microparticles of different origins demonstrated qualitatively different characteristics related to coagulation activation and propagation." @default.
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• W2997678088 date "2020-01-06" @default.
• W2997678088 modified "2023-09-26" @default.
• W2997678088 title "Platelet, erythrocyte, endothelial, and monocyte microparticles in coagulation activation and propagation" @default.
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• W2997678088 doi "https://doi.org/10.1101/2020.01.06.895722" @default.
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