FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997679303> ?p ?o ?g. }

• W2997679303 endingPage "129" @default.
• W2997679303 startingPage "119" @default.
• W2997679303 abstract "The immunosuppressive facet and tumorigenic role of TNF-α have been revealed in osteosarcoma (OS). Long noncoding RNA THRIL is identified to regulate TNF-α expression and participates in immune response. Thus, investigations on the clinical expression pattern of THRIL/TNF-α signal in OS would provide a potential target premise for OS patients.We collected OS (n=83), nontumor tissues (n=37) and serum samples (n=83 for OS and n=40 for healthy control) to determine the expressions and clinical significance of THRIL/TNF-α signal. Knockdown of THRIL in OS cell lines MG63 and Saos2 in vitro and in vivo was performed to confirm its function in the development of OS.Elevated expression of THRIL was associated with increased TNF-α levels in OS tissues and serum samples. Combination of THRIL and TNF-α in tissues showed a more efficient diagnostic value for OS patients than either of them. Moreover, high-expressed THRIL was associated with larger tumor size, advanced Enneking stage and lung metastasis, whereas high TNF-α expression was found in patients with high histologic grade and patients who simultaneously harbor high THRIL and TNF-α showed the worst overall survival and metastasis-free survival. TNF-α signals increased OS cell vitalities in vitro but knockdown of THRIL inhibited TNF-α expressions, leading to impaired cell vitality, increased apoptosis and also downregulated epithelial to mesenchymal transition (EMT) phenotype and the ability of invasion, but these processes were restored by the treatment of TNF-α. The oncogenic role of THRIL/TNF-α signal was also confirmed in the xenograft model of MG63 cells.Overexpressed THRIL and TNF-α promoted OS progression with efficient diagnostic and prognostic value. THRIL/TNF-α signal supported cell growth and EMT phenotype of OS cells in vitro and in vivo." @default.
• W2997679303 created "2020-01-10" @default.
• W2997679303 creator A5005180151 @default.
• W2997679303 creator A5030216533 @default.
• W2997679303 creator A5036016529 @default.
• W2997679303 creator A5036464713 @default.
• W2997679303 creator A5044571543 @default.
• W2997679303 creator A5063366241 @default.
• W2997679303 creator A5082941033 @default.
• W2997679303 creator A5086664284 @default.
• W2997679303 date "2020-01-01" @default.
• W2997679303 modified "2023-10-03" @default.
• W2997679303 title "<p>Upregulated lncRNA THRIL/TNF-α Signals Promote Cell Growth and Predict Poor Clinical Outcomes of Osteosarcoma</p>" @default.
• W2997679303 cites W1597449789 @default.
• W2997679303 cites W1915719235 @default.
• W2997679303 cites W2077768019 @default.
• W2997679303 cites W2133644362 @default.
• W2997679303 cites W2323661646 @default.
• W2997679303 cites W2342245047 @default.
• W2997679303 cites W2549670225 @default.
• W2997679303 cites W2736825224 @default.
• W2997679303 cites W2739632265 @default.
• W2997679303 cites W2765403010 @default.
• W2997679303 cites W2771381310 @default.
• W2997679303 cites W2780260597 @default.
• W2997679303 cites W2790186410 @default.
• W2997679303 cites W2790748465 @default.
• W2997679303 cites W2793322448 @default.
• W2997679303 cites W2793573307 @default.
• W2997679303 cites W2801082224 @default.
• W2997679303 cites W2811034860 @default.
• W2997679303 cites W2888130072 @default.
• W2997679303 cites W2902198814 @default.
• W2997679303 cites W2902479726 @default.
• W2997679303 cites W2902858309 @default.
• W2997679303 cites W2906095458 @default.
• W2997679303 cites W2942495572 @default.
• W2997679303 cites W2942675515 @default.
• W2997679303 cites W2946840107 @default.
• W2997679303 cites W2956091095 @default.
• W2997679303 cites W3098604411 @default.
• W2997679303 doi "https://doi.org/10.2147/ott.s235798" @default.
• W2997679303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6954829" @default.
• W2997679303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32021260" @default.
• W2997679303 hasPublicationYear "2020" @default.
• W2997679303 type Work @default.
• W2997679303 sameAs 2997679303 @default.
• W2997679303 citedByCount "12" @default.
• W2997679303 countsByYear W29976793032020 @default.
• W2997679303 countsByYear W29976793032021 @default.
• W2997679303 countsByYear W29976793032022 @default.
• W2997679303 countsByYear W29976793032023 @default.
• W2997679303 crossrefType "journal-article" @default.
• W2997679303 hasAuthorship W2997679303A5005180151 @default.
• W2997679303 hasAuthorship W2997679303A5030216533 @default.
• W2997679303 hasAuthorship W2997679303A5036016529 @default.
• W2997679303 hasAuthorship W2997679303A5036464713 @default.
• W2997679303 hasAuthorship W2997679303A5044571543 @default.
• W2997679303 hasAuthorship W2997679303A5063366241 @default.
• W2997679303 hasAuthorship W2997679303A5082941033 @default.
• W2997679303 hasAuthorship W2997679303A5086664284 @default.
• W2997679303 hasBestOaLocation W29976793031 @default.
• W2997679303 hasConcept C104317684 @default.
• W2997679303 hasConcept C121608353 @default.
• W2997679303 hasConcept C126322002 @default.
• W2997679303 hasConcept C127561419 @default.
• W2997679303 hasConcept C142724271 @default.
• W2997679303 hasConcept C1491633281 @default.
• W2997679303 hasConcept C150903083 @default.
• W2997679303 hasConcept C173396325 @default.
• W2997679303 hasConcept C17991360 @default.
• W2997679303 hasConcept C190283241 @default.
• W2997679303 hasConcept C198826908 @default.
• W2997679303 hasConcept C203014093 @default.
• W2997679303 hasConcept C207001950 @default.
• W2997679303 hasConcept C2777760704 @default.
• W2997679303 hasConcept C2778690821 @default.
• W2997679303 hasConcept C2779013556 @default.
• W2997679303 hasConcept C502942594 @default.
• W2997679303 hasConcept C54355233 @default.
• W2997679303 hasConcept C55493867 @default.
• W2997679303 hasConcept C62203573 @default.
• W2997679303 hasConcept C71924100 @default.
• W2997679303 hasConcept C86803240 @default.
• W2997679303 hasConcept C8891405 @default.
• W2997679303 hasConceptScore W2997679303C104317684 @default.
• W2997679303 hasConceptScore W2997679303C121608353 @default.
• W2997679303 hasConceptScore W2997679303C126322002 @default.
• W2997679303 hasConceptScore W2997679303C127561419 @default.
• W2997679303 hasConceptScore W2997679303C142724271 @default.
• W2997679303 hasConceptScore W2997679303C1491633281 @default.
• W2997679303 hasConceptScore W2997679303C150903083 @default.
• W2997679303 hasConceptScore W2997679303C173396325 @default.
• W2997679303 hasConceptScore W2997679303C17991360 @default.
• W2997679303 hasConceptScore W2997679303C190283241 @default.
• W2997679303 hasConceptScore W2997679303C198826908 @default.
• W2997679303 hasConceptScore W2997679303C203014093 @default.
• W2997679303 hasConceptScore W2997679303C207001950 @default.

• next