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- W2997682776 abstract "The present work reports on the synthesis and preliminary pharmacol. investigation of new 3-aryl-6,7-dimethyl-9-substituted thiazolo[3,2-a]benzimidazolium salts. These derivs. were synthesized by reacting the 3-aryl-6,7-dimethylthiazolo[3,2-a]benzimidazoles with the appropriate quaternizing agent. The latter compds. were, in turn prepd. by cyclodehydration of 5,6-dimethyl-2-(phenacylthio)benzimidazoles in polyphosphoric acid (PPA). The latter derivs. were obtained by the reaction of 5,6-dimethylbenzimidazole-2-thione with the appropriate phenacyl bromide. Some of the tested compds. have shown a pronounced hypoglycemic activity. The results do permit the assignment of compds. having N9-phenacyl entity as promising antidiabetic agents." @default.
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- W2997682776 date "2001-06-30" @default.
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- W2997682776 title "Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic" @default.
- W2997682776 doi "https://doi.org/10.21608/bfsa.2001.65750" @default.
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