Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997686935> ?p ?o ?g. }
- W2997686935 abstract "Abstract Receptology has been complicated with enhancements in our knowledge of G‐protein‐coupled‐receptor (GPCR) biochemistry. This complexity is exemplified by the pharmacology of melatonin receptors. Here, we describe the complexity of GPCR biochemistry in five dimensions: (a) receptor expression, particularly in organs/tissues that are only partially understood; (b) ligands and receptor‐associated proteins (interactome); (c) receptor function, which might be more complex than the known G‐protein‐coupled systems; (d) ligand bias, which favors a particular pathway; and (e) receptor dimerization, which might concern all receptors coexpressed in the same cell. Thus, receptor signaling might be modified or modulated, depending on the nature of the receptor complex. Fundamental studies are needed to clarify these points and find new ways to tackle receptor functionality. This opinion article emphasizes the global questions attached to new descriptions of GPCRs and aims to raise our awareness of the tremendous complexity of modern receptology." @default.
- W2997686935 created "2020-01-10" @default.
- W2997686935 creator A5016245843 @default.
- W2997686935 creator A5021383328 @default.
- W2997686935 date "2019-12-29" @default.
- W2997686935 modified "2023-09-28" @default.
- W2997686935 title "The five dimensions of receptor pharmacology exemplified by melatonin receptors: An opinion" @default.
- W2997686935 cites W1541441850 @default.
- W2997686935 cites W1557670531 @default.
- W2997686935 cites W1828997066 @default.
- W2997686935 cites W1908097433 @default.
- W2997686935 cites W1971251923 @default.
- W2997686935 cites W1971565874 @default.
- W2997686935 cites W1971967263 @default.
- W2997686935 cites W1979693948 @default.
- W2997686935 cites W2000086793 @default.
- W2997686935 cites W2015136750 @default.
- W2997686935 cites W2015324181 @default.
- W2997686935 cites W2022364867 @default.
- W2997686935 cites W2025390721 @default.
- W2997686935 cites W2028004193 @default.
- W2997686935 cites W2030643938 @default.
- W2997686935 cites W2031343184 @default.
- W2997686935 cites W2034198913 @default.
- W2997686935 cites W2036673125 @default.
- W2997686935 cites W2038544609 @default.
- W2997686935 cites W2041476545 @default.
- W2997686935 cites W2048504220 @default.
- W2997686935 cites W2051106500 @default.
- W2997686935 cites W2051274206 @default.
- W2997686935 cites W2053430956 @default.
- W2997686935 cites W2054641638 @default.
- W2997686935 cites W2059085109 @default.
- W2997686935 cites W2064264742 @default.
- W2997686935 cites W2067599429 @default.
- W2997686935 cites W2069915228 @default.
- W2997686935 cites W2073037108 @default.
- W2997686935 cites W2073622913 @default.
- W2997686935 cites W2076789904 @default.
- W2997686935 cites W2083720843 @default.
- W2997686935 cites W2086017575 @default.
- W2997686935 cites W2091646716 @default.
- W2997686935 cites W2099787261 @default.
- W2997686935 cites W2106497761 @default.
- W2997686935 cites W2108846443 @default.
- W2997686935 cites W2111216537 @default.
- W2997686935 cites W2116473569 @default.
- W2997686935 cites W2126205569 @default.
- W2997686935 cites W2127817557 @default.
- W2997686935 cites W2132245233 @default.
- W2997686935 cites W2134185564 @default.
- W2997686935 cites W2136228105 @default.
- W2997686935 cites W2138325877 @default.
- W2997686935 cites W2141956263 @default.
- W2997686935 cites W2142082526 @default.
- W2997686935 cites W2166430034 @default.
- W2997686935 cites W2168275634 @default.
- W2997686935 cites W2226350994 @default.
- W2997686935 cites W2239689295 @default.
- W2997686935 cites W2272096593 @default.
- W2997686935 cites W2288077045 @default.
- W2997686935 cites W2442143867 @default.
- W2997686935 cites W2460162654 @default.
- W2997686935 cites W2479394673 @default.
- W2997686935 cites W2493364917 @default.
- W2997686935 cites W2566927390 @default.
- W2997686935 cites W2590726321 @default.
- W2997686935 cites W2599427022 @default.
- W2997686935 cites W2613301616 @default.
- W2997686935 cites W2617897061 @default.
- W2997686935 cites W2730889053 @default.
- W2997686935 cites W2734591620 @default.
- W2997686935 cites W2765153686 @default.
- W2997686935 cites W2765403125 @default.
- W2997686935 cites W2770745380 @default.
- W2997686935 cites W2780167836 @default.
- W2997686935 cites W2782382515 @default.
- W2997686935 cites W2784321341 @default.
- W2997686935 cites W2793896555 @default.
- W2997686935 cites W2894359122 @default.
- W2997686935 cites W2899596245 @default.
- W2997686935 cites W2902075097 @default.
- W2997686935 cites W2905372434 @default.
- W2997686935 cites W2940668662 @default.
- W2997686935 cites W2941699811 @default.
- W2997686935 cites W2951895401 @default.
- W2997686935 cites W2969654250 @default.
- W2997686935 cites W2989558653 @default.
- W2997686935 cites W48759033 @default.
- W2997686935 cites W59160640 @default.
- W2997686935 doi "https://doi.org/10.1002/prp2.556" @default.
- W2997686935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6935684" @default.
- W2997686935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31893125" @default.
- W2997686935 hasPublicationYear "2019" @default.
- W2997686935 type Work @default.
- W2997686935 sameAs 2997686935 @default.
- W2997686935 citedByCount "15" @default.
- W2997686935 countsByYear W29976869352020 @default.
- W2997686935 countsByYear W29976869352021 @default.
- W2997686935 countsByYear W29976869352022 @default.