FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997692605> ?p ?o ?g. }

• W2997692605 endingPage "71" @default.
• W2997692605 startingPage "65" @default.
• W2997692605 abstract "To explore the effects of huayu tongluo (resolving stasis, promoting collateral circulation) moxibustion on learning and memory ability and the expressions of brain derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) in the rats of vascular dementia (VD) in the microenvironment of neurovascular niche.Using 2-vessel occlusion (2-VO), the VD rat models were duplicated. The neural stem cells (NSCs) labeled with lentiviral vector-mediated enhanced green fluorescent protein (EGFP) were co-cultured with endothelial progenitor cells (EPCs) to structure the NSCs + EPCs implant. The implant was transplanted into the lateral ventricle of VD rats and the VD rat models with neurovascular niche were established. In No.1 experiment, the successful-modeled rats were divided into 3 groups, i.e. a NSCs + EPCs moxibustion group, a NSCs + EPCs blank group and a model group, 12 rats in each one. No any treatment was provided in the model group and the NSCs + EPCs blank group. The huayu tongluo moxibustion therapy was adopted in the NSCs + EPCs moxibustion group, in which, the suspending moxibustion technique was applied to Baihui (GV 20), Dazhui (GV 14) and Shenting (GV 24), 20 min at each acupoint. The treatment was given once every day and a 14-day treatment was as one course. Totally, 3 courses of treatment were required. At the end of treatment, Morris water maze experiment was adopted to determine the learning and memory ability of the rats in each group. In the No.2 experiment, the model rats were divided into 3 groups, a NSCs + EPCs moxibustion group, a NSCs + EPCs blank group and a model group, 18 rats in each one. In each group, according to the durations of treatment, 3 subgroups were divided and 6 rats in each one. The intervention method was same as the No.1 experiment. Additionally, after corresponding treatment course, using perfusion, the brains were collected in each subgroup and the slices were frozen. BDNF/TrkB expressions were observed in the immunofluorescence test.After treatment, in the NSCs + EPCs moxibustion group, the escape incubation was reduced, the time of the first running-cross platform was shortened and the frequency of running-cross platform increased as compared with the model group and the NSCs + EPCs blank group (P<0.01, P<0.05). The protein expressions were increased in tendency among the 3 courses of treatment in the NSCs + EPCs moxibustion group, indicating the significant differences (all P<0.05), in which, the increase of the protein expressions in the NSCs + EPCs moxibustion group was better than the NSCs + EPCs blank group (P<0.05, P<0.01).The huayu tongluo moxibustion therapy is the effective approach to VD in clinical treatment. This therapy up-regulates the BDNF/TrkB protein expressions in the microenvironment of neurovascular niche, co-modulates NSCs-EPCs coupling mechanism, promotes nerve neogenesis and repairs the injured nerve." @default.
• W2997692605 created "2020-01-10" @default.
• W2997692605 creator A5014182016 @default.
• W2997692605 creator A5025328838 @default.
• W2997692605 creator A5026941855 @default.
• W2997692605 creator A5028179790 @default.
• W2997692605 creator A5032344292 @default.
• W2997692605 creator A5066562420 @default.
• W2997692605 creator A5067327146 @default.
• W2997692605 date "2019-01-12" @default.
• W2997692605 modified "2023-09-23" @default.
• W2997692605 title "[Effects of huayu tongluo moxibustion on learning and memory ability and the hippocampal BDNF/TrkB expressions in the rats of vascular dementia]." @default.
• W2997692605 doi "https://doi.org/10.13703/j.0255-2930.2019.01.014" @default.
• W2997692605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30672259" @default.
• W2997692605 hasPublicationYear "2019" @default.
• W2997692605 type Work @default.
• W2997692605 sameAs 2997692605 @default.
• W2997692605 citedByCount "0" @default.
• W2997692605 crossrefType "journal-article" @default.
• W2997692605 hasAuthorship W2997692605A5014182016 @default.
• W2997692605 hasAuthorship W2997692605A5025328838 @default.
• W2997692605 hasAuthorship W2997692605A5026941855 @default.
• W2997692605 hasAuthorship W2997692605A5028179790 @default.
• W2997692605 hasAuthorship W2997692605A5032344292 @default.
• W2997692605 hasAuthorship W2997692605A5066562420 @default.
• W2997692605 hasAuthorship W2997692605A5067327146 @default.
• W2997692605 hasConcept C126322002 @default.
• W2997692605 hasConcept C134018914 @default.
• W2997692605 hasConcept C136834591 @default.
• W2997692605 hasConcept C142724271 @default.
• W2997692605 hasConcept C148762608 @default.
• W2997692605 hasConcept C160539049 @default.
• W2997692605 hasConcept C167734588 @default.
• W2997692605 hasConcept C170493617 @default.
• W2997692605 hasConcept C201750760 @default.
• W2997692605 hasConcept C204787440 @default.
• W2997692605 hasConcept C2777025900 @default.
• W2997692605 hasConcept C2777674692 @default.
• W2997692605 hasConcept C2777952318 @default.
• W2997692605 hasConcept C2779134260 @default.
• W2997692605 hasConcept C2779483572 @default.
• W2997692605 hasConcept C2781161787 @default.
• W2997692605 hasConcept C28328180 @default.
• W2997692605 hasConcept C44752575 @default.
• W2997692605 hasConcept C56837625 @default.
• W2997692605 hasConcept C71924100 @default.
• W2997692605 hasConcept C86803240 @default.
• W2997692605 hasConcept C95444343 @default.
• W2997692605 hasConcept C97124661 @default.
• W2997692605 hasConceptScore W2997692605C126322002 @default.
• W2997692605 hasConceptScore W2997692605C134018914 @default.
• W2997692605 hasConceptScore W2997692605C136834591 @default.
• W2997692605 hasConceptScore W2997692605C142724271 @default.
• W2997692605 hasConceptScore W2997692605C148762608 @default.
• W2997692605 hasConceptScore W2997692605C160539049 @default.
• W2997692605 hasConceptScore W2997692605C167734588 @default.
• W2997692605 hasConceptScore W2997692605C170493617 @default.
• W2997692605 hasConceptScore W2997692605C201750760 @default.
• W2997692605 hasConceptScore W2997692605C204787440 @default.
• W2997692605 hasConceptScore W2997692605C2777025900 @default.
• W2997692605 hasConceptScore W2997692605C2777674692 @default.
• W2997692605 hasConceptScore W2997692605C2777952318 @default.
• W2997692605 hasConceptScore W2997692605C2779134260 @default.
• W2997692605 hasConceptScore W2997692605C2779483572 @default.
• W2997692605 hasConceptScore W2997692605C2781161787 @default.
• W2997692605 hasConceptScore W2997692605C28328180 @default.
• W2997692605 hasConceptScore W2997692605C44752575 @default.
• W2997692605 hasConceptScore W2997692605C56837625 @default.
• W2997692605 hasConceptScore W2997692605C71924100 @default.
• W2997692605 hasConceptScore W2997692605C86803240 @default.
• W2997692605 hasConceptScore W2997692605C95444343 @default.
• W2997692605 hasConceptScore W2997692605C97124661 @default.
• W2997692605 hasIssue "1" @default.
• W2997692605 hasLocation W29976926051 @default.
• W2997692605 hasOpenAccess W2997692605 @default.
• W2997692605 hasPrimaryLocation W29976926051 @default.
• W2997692605 hasRelatedWork W1983951432 @default.
• W2997692605 hasRelatedWork W2039176479 @default.
• W2997692605 hasRelatedWork W2053426458 @default.
• W2997692605 hasRelatedWork W2072536549 @default.
• W2997692605 hasRelatedWork W2360253029 @default.
• W2997692605 hasRelatedWork W2372411244 @default.
• W2997692605 hasRelatedWork W2374442854 @default.
• W2997692605 hasRelatedWork W2380431390 @default.
• W2997692605 hasRelatedWork W2800037979 @default.
• W2997692605 hasRelatedWork W2997692605 @default.
• W2997692605 hasVolume "39" @default.
• W2997692605 isParatext "false" @default.
• W2997692605 isRetracted "false" @default.
• W2997692605 magId "2997692605" @default.
• W2997692605 workType "article" @default.