Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997694310> ?p ?o ?g. }
- W2997694310 abstract "AMP‑activated protein kinase (AMPK) is an ubiquitously expressed serine/threonine kinase and an important regulator of energy metabolism. The decreased activity of AMPK induced by low‑grade chronic inflammation has been implicated in several diseases, including type 2 diabetes and atherosclerosis. However, the activation of AMPK by natural and synthetic products can ameliorate these diseases through the inhibition of inflammation. For example, aged garlic extract (AGE) has been shown to enhance the phosphorylation of Thr172 of the α‑subunit of AMPK in several tissues of disease model animals. In addition, AGE has been reported to suppress the progression of atherosclerotic plaque formation in an animal model of atherosclerosis. Moreover, AGE has been found to decrease the level of plasma glycated albumin and to improve hyperglycemia in an animal model of type 2 diabetes. These inhibitory effects of AGE are induced by the suppression of the inflammatory response. In the present review, we discuss the mechanisms through which AGE activates AMPK, as well as the mechanisms through which the activation of AMPK by AGE modulates the inflammatory response in disease models." @default.
- W2997694310 created "2020-01-10" @default.
- W2997694310 creator A5026989804 @default.
- W2997694310 creator A5029365658 @default.
- W2997694310 creator A5042222325 @default.
- W2997694310 creator A5060157290 @default.
- W2997694310 date "2019-12-27" @default.
- W2997694310 modified "2023-09-27" @default.
- W2997694310 title "Mechanisms underlying the attenuation of chronic inflammatory diseases by aged garlic extract: Involvement of the activation of AMP‑activated protein kinase (Review)" @default.
- W2997694310 cites W1523693806 @default.
- W2997694310 cites W1587781698 @default.
- W2997694310 cites W1615432648 @default.
- W2997694310 cites W1763748172 @default.
- W2997694310 cites W1874251201 @default.
- W2997694310 cites W1964188773 @default.
- W2997694310 cites W1964607854 @default.
- W2997694310 cites W1967161323 @default.
- W2997694310 cites W1967667786 @default.
- W2997694310 cites W1969976773 @default.
- W2997694310 cites W1975877581 @default.
- W2997694310 cites W1983419107 @default.
- W2997694310 cites W2011574523 @default.
- W2997694310 cites W2015984569 @default.
- W2997694310 cites W2016752484 @default.
- W2997694310 cites W2027635563 @default.
- W2997694310 cites W2031882974 @default.
- W2997694310 cites W2043447398 @default.
- W2997694310 cites W2056817651 @default.
- W2997694310 cites W2070293380 @default.
- W2997694310 cites W2070485667 @default.
- W2997694310 cites W2078374645 @default.
- W2997694310 cites W2078575160 @default.
- W2997694310 cites W2079580613 @default.
- W2997694310 cites W2101812837 @default.
- W2997694310 cites W2103854085 @default.
- W2997694310 cites W2104197032 @default.
- W2997694310 cites W2111322904 @default.
- W2997694310 cites W2115957809 @default.
- W2997694310 cites W2117680364 @default.
- W2997694310 cites W2119008227 @default.
- W2997694310 cites W2121106906 @default.
- W2997694310 cites W2125344123 @default.
- W2997694310 cites W2126929570 @default.
- W2997694310 cites W2129043128 @default.
- W2997694310 cites W2132099317 @default.
- W2997694310 cites W2140415161 @default.
- W2997694310 cites W2141535239 @default.
- W2997694310 cites W2144600435 @default.
- W2997694310 cites W2145417168 @default.
- W2997694310 cites W2152377123 @default.
- W2997694310 cites W2153399820 @default.
- W2997694310 cites W2165604976 @default.
- W2997694310 cites W2194227846 @default.
- W2997694310 cites W2233911163 @default.
- W2997694310 cites W2236927123 @default.
- W2997694310 cites W2237995385 @default.
- W2997694310 cites W2263464972 @default.
- W2997694310 cites W2274007822 @default.
- W2997694310 cites W2282936473 @default.
- W2997694310 cites W2317113145 @default.
- W2997694310 cites W2407256458 @default.
- W2997694310 cites W2475030461 @default.
- W2997694310 cites W2495789718 @default.
- W2997694310 cites W2530157596 @default.
- W2997694310 cites W2555230408 @default.
- W2997694310 cites W2558605920 @default.
- W2997694310 cites W2559925992 @default.
- W2997694310 cites W2572191046 @default.
- W2997694310 cites W2581971658 @default.
- W2997694310 cites W2598569906 @default.
- W2997694310 cites W2625887862 @default.
- W2997694310 cites W2739159777 @default.
- W2997694310 cites W2743010525 @default.
- W2997694310 cites W2750246658 @default.
- W2997694310 cites W2759601860 @default.
- W2997694310 cites W2765926634 @default.
- W2997694310 cites W2781518723 @default.
- W2997694310 cites W2791237606 @default.
- W2997694310 cites W2797166244 @default.
- W2997694310 cites W2809632591 @default.
- W2997694310 cites W2891236012 @default.
- W2997694310 cites W2892467853 @default.
- W2997694310 cites W2899175683 @default.
- W2997694310 cites W2904878795 @default.
- W2997694310 cites W2909448498 @default.
- W2997694310 cites W2920248606 @default.
- W2997694310 cites W2940648607 @default.
- W2997694310 cites W4230437644 @default.
- W2997694310 cites W44929223 @default.
- W2997694310 doi "https://doi.org/10.3892/etm.2019.8372" @default.
- W2997694310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6966139" @default.
- W2997694310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32010323" @default.
- W2997694310 hasPublicationYear "2019" @default.
- W2997694310 type Work @default.
- W2997694310 sameAs 2997694310 @default.
- W2997694310 citedByCount "5" @default.
- W2997694310 countsByYear W29976943102020 @default.
- W2997694310 countsByYear W29976943102021 @default.
- W2997694310 countsByYear W29976943102022 @default.
- W2997694310 countsByYear W29976943102023 @default.