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- W2997746773 abstract "Background: Lymph node yield (LNY) is an indicator of oncological adequacy of surgery for pancreatic adenocarcinoma (PAC). However, it is unclear if a standardized pathological examination (SPE) aimed at accurate staging can increase the LNY. If SPE cannot achieve a higher LNY, there is an argument for re-evaluating and modifying the surgical technique (ST) to increase its radicality. If, however, SPE increases the LNY, this may indicate appropriate ST, but previously improper pathology work-up. Methods: After the introduction of SPE at Oslo University Hospital, data were collected prospectively on patients with PAC undergoing laparoscopic distal pancreatectomy. Results were compared with retrospective data from the specimens examined in a non-standardized way (NSPE). Patients undergoing en-bloc resection of adjacent organ(s), conversion to open surgery and those with IPMN-carcinoma were excluded. Results: SPE and NSPE were applied to 16 and 33 specimens, respectively. SPE was associated with a higher LNY and higher median number of positive lymph nodes (p=0.001 and p=0.03, respectively). In the stepwise regression model, SPE and younger age resulted in an increased LNY. In the logistic regression model, LNY and tumor size positively correlated with N1 stage. Conclusion: SPE is associated with higher LNY in patients with PAC, which increases the likelihood of detecting positive lymph nodes and reduces the risk of understaging. These findings also indicate that ST is adequate." @default.
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- W2997746773 date "2019-01-01" @default.
- W2997746773 modified "2023-09-30" @default.
- W2997746773 title "Improved lymph node yield in laparoscopic distal pancreatectomy specimens in patients with pancreatic adenocarcinoma" @default.
- W2997746773 doi "https://doi.org/10.1016/j.hpb.2019.10.570" @default.
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