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- W2997748392 abstract "The oviductal fluid is the first environment experienced by mammalian embryos at the very beginning of life. However, it has long been believed that the oviductal environment was not essential for proper embryonic development. Successful establishment of in vitro embryo production techniques (which completely bypass the oviduct) have reinforced this idea. Yet, it became evident that in vitro produced embryos differ markedly from their in vivo counterparts, and these differences are associated with lower pregnancy outcomes and more health issues after birth. Nowadays, researchers consider the oviduct as the most suitable microenvironment for early embryonic development and a substantial effort is made to understand its dynamic, species-specific functions. In this review, we touch on the origin and molecular components of the oviductal fluid in mammals, where recent progress has been made thanks to the wider use of mass spectrometry techniques. Some of the factors and processes known to regulate oviductal secretions, including the embryo itself, as well as ovulation, insemination, endogenous and exogenous hormones, and metabolic and heat stress, are summarized. Special emphasis is laid on farm animals because, owing to the availability of sample material and the economic importance of fertility in livestock husbandry, a large part of the work on this topic has been carried out in domestic animals used for dairy and/or meat production." @default.
- W2997748392 created "2020-01-10" @default.
- W2997748392 creator A5016732838 @default.
- W2997748392 creator A5024981277 @default.
- W2997748392 creator A5055752130 @default.
- W2997748392 creator A5056945033 @default.
- W2997748392 creator A5084114694 @default.
- W2997748392 date "2019-12-28" @default.
- W2997748392 modified "2023-10-18" @default.
- W2997748392 title "Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions" @default.
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