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• W2997771913 endingPage "110824" @default.
• W2997771913 startingPage "110824" @default.
• W2997771913 abstract "Skeletal muscle quality and quantity are negatively impacted with age. Part of this decline in function can be attributed to alterations in mitochondrial turnover, and in the mechanisms that regulate mitochondrial homeostasis. Protein quality control within the mitochondria relies on a number of interconnected processes, namely the mitochondrial unfolded protein response (UPR mt ), protein import and mitophagy. In particular, the post-transcriptional regulation of protein import into the organelle has generated considerable recent interest in view of its dynamic versatility. The capacity for import can be increased by chronic exercise, and diminished by muscle disuse, and defects in the import pathway can be rescued by exercise. Within mitochondria, the unfolded protein response (UPR) is activated if protein import is altered, or if protein misfolding takes place. This UPR generates retrograde signaling to the nucleus to activate compensatory gene expression and protein synthesis. Mitophagy is also elevated with age, contributing to the lower mitochondrial content in aging muscle. However, mitophagy is amenable to exercise adaptations, as it is activated with each exercise bout, presumably to mediate mitochondrial quality control. However, this response is attenuated in older subjects. Although not yet completely elucidated, numerous molecular processes involved in mitochondrial biogenesis and turnover are affected with age. The contrasting and often opposite consequences of exercise and age suggest that exercise can serve as non-pharmacological “mitochondrial medicine” for aging muscle to ameliorate mitochondrial content and function, via pathways that implicate organelle protein quality control mechanisms. • Mitochondrial quality is contingent on the integration of a number of pathways. • Pathways include: protein import, the unfolded protein response and mitophagy. • Exercise modifies mitochondrial quality control. • Mitochondrial defects with age can be attenuated with exercise." @default.
• W2997771913 created "2020-01-10" @default.
• W2997771913 creator A5010199453 @default.
• W2997771913 creator A5032275371 @default.
• W2997771913 creator A5076563879 @default.
• W2997771913 date "2020-03-01" @default.
• W2997771913 modified "2023-09-27" @default.
• W2997771913 title "The intersection of exercise and aging on mitochondrial protein quality control" @default.
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