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- W2997790589 abstract "Chemotherapy treatment and autologous and allogeneic cell transplantations are often complicated by the onset of metabolic and endocrine disorders. Autoimmune disorders, metabolic diseases, and hormonal dysfunctions are some of the endocrine complications observed during or after treatment with immunotherapy (mostly novel agents) and/or chemotherapy conditioning for transplantation. Although successful treatment of the underlying hematological condition often improves the dysfunction, endocrinopathies can have an impact on prognosis and are associated with poor survival; therefore, it is important to detect and treat them as early as possible. An increased incidence of cardiovascular diseases and metabolic syndrome has been observed after transplantation mostly in long-term survivors. In addition, chemotherapy and radiation along with the prolonged use of corticosteroids can contribute to the onset of thyroid and gonadal dysfunctions. The aim of this article is to describe metabolic dysfunctions occurring in patients who underwent allogeneic cell transplantation.Kemoterapi tedavisi ve otolog ve allojeneik hücre transplantasyonları, metabolik ve endokrin bozuklukların başlaması ile sıklıkla komplike olmaktadır. Otoimmün bozukluklar, metabolik hastalıklar, ve hormonal disfonksiyonlar immünoterapi (çoğunlukla yeni ajanlar) ve/veya transplantasyon için uygulanan hazırlama rejimi sırasında veya sonrasında gözlenen bazı endokrin komplikasyonlardır. Altta yatan hematolojik durumun başarılı tedavisi endokrin disfonksiyonu sıklıkla iyileştirmekle birlikte, endokrinopatilerin prognoz üzerine etkisi olabilir ve kısa yaşam süresi ile ilişkilidir; bu nedenle mümkün olduğu kadar erken saptanmaları ve tedavi edilmeleri önemlidir. Çoğunlukla uzun dönem sağkalan hastalarda transplantasyon sonrası kardiyovasküler hastalıklar ve metabolik sendromun insidansında artma gözlenmektedir. Ek olarak, kortikosteroidlerin uzun süreli kullanımı ile birlikte kemoterapi ve radyoterapi tiroid ve gonadal bozuklukların başlamasına katkıda bulunabilir. Bu yazının amacı allojeneik kök hücre transplantasyonu uygulanan hastalarda metabolik bozuklukların anlatılmasıdır." @default.
- W2997790589 created "2020-01-10" @default.
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- W2997790589 date "2019-12-25" @default.
- W2997790589 modified "2023-10-17" @default.
- W2997790589 title "Endocrine and Metabolic Disorders After Hematopoietic Stem Cell Transplantation Annalisa Paviglianiti Metabolic Diseases in Hematology" @default.
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- W2997790589 doi "https://doi.org/10.4274/tjh.galenos.2019.2019.0248" @default.
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