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- W2997803431 abstract "Enzymatic and post-translational modifications (PTMs) such as ubiquitination, acetylation, and methylation occur at lysine residues. The PTMs play critical roles in the regulation of the protein functions, and thus, various cellular processes. In addition, aberrations of the PTMs are associated with various diseases, such as cancer and neurodegenerative disorders. Therefore, we hypothesized that modulation of the PTMs and normalization of the PTM abnormalities could be useful as methods to control various cellular mechanisms and as a therapeutic strategy, respectively. To modulate the PTMs, we have focused on lysine-modifying enzymes and have pursued drug discovery researches on ubiquitination inducers, lysine deacetylase (KDAC) inhibitors, and lysine demethylase (KDM) inhibitors. For the identification of the modulators, we have used not only conventional drug design, such as structure-based drug design (SBDD) and ligand-based drug design (LBDD), but also strategic chemistry approaches, such as drug design based on enzyme catalytic mechanism. As a result, we have identified several modulators which have pharmacological effects in animal models or in cellular studies. In this review, focusing on the drug design based on enzyme catalytic mechanism, our drug discovery researches have been discussed." @default.
- W2997803431 created "2020-01-10" @default.
- W2997803431 creator A5052910102 @default.
- W2997803431 date "2020-01-01" @default.
- W2997803431 modified "2023-10-14" @default.
- W2997803431 title "Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches" @default.
- W2997803431 cites W1023820744 @default.
- W2997803431 cites W1512690422 @default.
- W2997803431 cites W1563624749 @default.
- W2997803431 cites W1565539350 @default.
- W2997803431 cites W1964969734 @default.
- W2997803431 cites W1965243701 @default.
- W2997803431 cites W1969883059 @default.
- W2997803431 cites W1970210902 @default.
- W2997803431 cites W1971170829 @default.
- W2997803431 cites W1974322725 @default.
- W2997803431 cites W1977444445 @default.
- W2997803431 cites W1978876482 @default.
- W2997803431 cites W1980639672 @default.
- W2997803431 cites W1981549228 @default.
- W2997803431 cites W1983532163 @default.
- W2997803431 cites W1984109291 @default.
- W2997803431 cites W1984135970 @default.
- W2997803431 cites W1985712067 @default.
- W2997803431 cites W1986004978 @default.
- W2997803431 cites W1986231077 @default.
- W2997803431 cites W1988833818 @default.
- W2997803431 cites W1988884933 @default.
- W2997803431 cites W1989960958 @default.
- W2997803431 cites W1994287097 @default.
- W2997803431 cites W1995079678 @default.
- W2997803431 cites W1995511322 @default.
- W2997803431 cites W1998499089 @default.
- W2997803431 cites W2001232767 @default.
- W2997803431 cites W2001417240 @default.
- W2997803431 cites W2007774805 @default.
- W2997803431 cites W2009826707 @default.
- W2997803431 cites W2013810007 @default.
- W2997803431 cites W2015273986 @default.
- W2997803431 cites W2015416439 @default.
- W2997803431 cites W2020414099 @default.
- W2997803431 cites W2026029935 @default.
- W2997803431 cites W2029671140 @default.
- W2997803431 cites W2029689327 @default.
- W2997803431 cites W2031227366 @default.
- W2997803431 cites W2032232569 @default.
- W2997803431 cites W2035550797 @default.
- W2997803431 cites W2037215281 @default.
- W2997803431 cites W2037817306 @default.
- W2997803431 cites W2038054564 @default.
- W2997803431 cites W2040025688 @default.
- W2997803431 cites W2040462263 @default.
- W2997803431 cites W2042629507 @default.
- W2997803431 cites W2044513730 @default.
- W2997803431 cites W2049482823 @default.
- W2997803431 cites W2050148731 @default.
- W2997803431 cites W2051615431 @default.
- W2997803431 cites W2064261519 @default.
- W2997803431 cites W2064887977 @default.
- W2997803431 cites W2064959533 @default.
- W2997803431 cites W2065364505 @default.
- W2997803431 cites W2068200486 @default.
- W2997803431 cites W2070063830 @default.
- W2997803431 cites W2074899694 @default.
- W2997803431 cites W2076333986 @default.
- W2997803431 cites W2077082854 @default.
- W2997803431 cites W2079484553 @default.
- W2997803431 cites W2081685122 @default.
- W2997803431 cites W2084885369 @default.
- W2997803431 cites W2084897147 @default.
- W2997803431 cites W2085646898 @default.
- W2997803431 cites W2094153604 @default.
- W2997803431 cites W2096083625 @default.
- W2997803431 cites W2098356010 @default.
- W2997803431 cites W2101994612 @default.
- W2997803431 cites W2104726963 @default.
- W2997803431 cites W2107037828 @default.
- W2997803431 cites W2112937062 @default.
- W2997803431 cites W2113056756 @default.
- W2997803431 cites W2115232295 @default.
- W2997803431 cites W2117247812 @default.
- W2997803431 cites W2120450507 @default.
- W2997803431 cites W2120608933 @default.
- W2997803431 cites W2122256734 @default.
- W2997803431 cites W2125161768 @default.
- W2997803431 cites W2129608054 @default.
- W2997803431 cites W2131752445 @default.
- W2997803431 cites W2133388311 @default.
- W2997803431 cites W2142303705 @default.
- W2997803431 cites W2147524392 @default.
- W2997803431 cites W2148310814 @default.
- W2997803431 cites W2150804079 @default.
- W2997803431 cites W2163767810 @default.
- W2997803431 cites W2166987747 @default.
- W2997803431 cites W2168491902 @default.
- W2997803431 cites W2171293133 @default.
- W2997803431 cites W2171598595 @default.
- W2997803431 cites W2175488285 @default.