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- W2997805831 abstract "Intraperitoneal (IP) route of drug administration in laboratory animals is a common practice in many in vivo studies of disease models. While this route is an easy to master, quick, suitable for chronic treatments and with low impact of stress on laboratory rodents, there is a common concern that it may not be an acceptable route for drug administration in experimental studies. The latter is likely due to sparsity of information regarding pharmacokinetics of pharmacological agents and the mechanisms through which agents get systemic exposure after IP administration. In this review, we summarize the main mechanisms involved in bioavailability of IP administered drugs and provide examples of pharmacokinetic profiles for small and large molecules in comparison to other routes of administration. We conclude with a notion that IP administration of drugs in experimental studies involving rodents is a justifiable route for pharmacological and proof-of-concept studies where the goal is to evaluate the effect(s) of target engagement rather than properties of a drug formulation and/or its pharmacokinetics for clinical translation." @default.
- W2997805831 created "2020-01-10" @default.
- W2997805831 creator A5005705629 @default.
- W2997805831 creator A5012373686 @default.
- W2997805831 creator A5037761449 @default.
- W2997805831 date "2019-12-23" @default.
- W2997805831 modified "2023-10-17" @default.
- W2997805831 title "Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?" @default.
- W2997805831 cites W115498673 @default.
- W2997805831 cites W137099265 @default.
- W2997805831 cites W163980381 @default.
- W2997805831 cites W1752184720 @default.
- W2997805831 cites W1786602138 @default.
- W2997805831 cites W1890254882 @default.
- W2997805831 cites W1897698180 @default.
- W2997805831 cites W1903690808 @default.
- W2997805831 cites W1965500423 @default.
- W2997805831 cites W1968614039 @default.
- W2997805831 cites W1969951251 @default.
- W2997805831 cites W1971748739 @default.
- W2997805831 cites W1973011595 @default.
- W2997805831 cites W1974583723 @default.
- W2997805831 cites W1986432433 @default.
- W2997805831 cites W1993072922 @default.
- W2997805831 cites W1993396387 @default.
- W2997805831 cites W1996960578 @default.
- W2997805831 cites W1997722297 @default.
- W2997805831 cites W2000185101 @default.
- W2997805831 cites W2009214859 @default.
- W2997805831 cites W2009918976 @default.
- W2997805831 cites W2012104713 @default.
- W2997805831 cites W2017093973 @default.
- W2997805831 cites W2017208654 @default.
- W2997805831 cites W2021392062 @default.
- W2997805831 cites W2021933016 @default.
- W2997805831 cites W2022012581 @default.
- W2997805831 cites W2022780383 @default.
- W2997805831 cites W2024564976 @default.
- W2997805831 cites W2024689470 @default.
- W2997805831 cites W2024927304 @default.
- W2997805831 cites W2029265259 @default.
- W2997805831 cites W2038417739 @default.
- W2997805831 cites W2044182035 @default.
- W2997805831 cites W2045354824 @default.
- W2997805831 cites W2050311343 @default.
- W2997805831 cites W2052029336 @default.
- W2997805831 cites W2053246365 @default.
- W2997805831 cites W2055586281 @default.
- W2997805831 cites W2056808442 @default.
- W2997805831 cites W2056938528 @default.
- W2997805831 cites W2060589554 @default.
- W2997805831 cites W2061559135 @default.
- W2997805831 cites W2067515233 @default.
- W2997805831 cites W2070025581 @default.
- W2997805831 cites W2071684818 @default.
- W2997805831 cites W2076610833 @default.
- W2997805831 cites W2079800469 @default.
- W2997805831 cites W2080352981 @default.
- W2997805831 cites W2080442169 @default.
- W2997805831 cites W2083893369 @default.
- W2997805831 cites W2084323117 @default.
- W2997805831 cites W2085652943 @default.
- W2997805831 cites W2088533997 @default.
- W2997805831 cites W2088928063 @default.
- W2997805831 cites W2101894153 @default.
- W2997805831 cites W2103032351 @default.
- W2997805831 cites W2106243495 @default.
- W2997805831 cites W2111834967 @default.
- W2997805831 cites W2115897089 @default.
- W2997805831 cites W2119224395 @default.
- W2997805831 cites W2122884255 @default.
- W2997805831 cites W2128527026 @default.
- W2997805831 cites W2129179416 @default.
- W2997805831 cites W2133387698 @default.
- W2997805831 cites W2139130689 @default.
- W2997805831 cites W2141217262 @default.
- W2997805831 cites W2150732944 @default.
- W2997805831 cites W2165265744 @default.
- W2997805831 cites W2166443273 @default.
- W2997805831 cites W2168939314 @default.
- W2997805831 cites W2170197301 @default.
- W2997805831 cites W2180325798 @default.
- W2997805831 cites W2183540565 @default.
- W2997805831 cites W2253355615 @default.
- W2997805831 cites W2310076180 @default.
- W2997805831 cites W2313124741 @default.
- W2997805831 cites W2315799418 @default.
- W2997805831 cites W2317572142 @default.
- W2997805831 cites W2327583185 @default.
- W2997805831 cites W2335479685 @default.
- W2997805831 cites W2341574240 @default.
- W2997805831 cites W2394923862 @default.
- W2997805831 cites W2402239277 @default.
- W2997805831 cites W2405286029 @default.
- W2997805831 cites W2407406778 @default.
- W2997805831 cites W2408120219 @default.
- W2997805831 cites W2408610129 @default.
- W2997805831 cites W2409584455 @default.
- W2997805831 cites W2416607278 @default.
- W2997805831 cites W2417183606 @default.