FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997808550> ?p ?o ?g. }

• W2997808550 endingPage "446e" @default.
• W2997808550 startingPage "445e" @default.
• W2997808550 abstract "Sir: We thank Drs. Roncati and Piscioli for their insightful comments regarding our work examining vertical growth phase as a prognostic factor for sentinel lymph node positivity in thin melanomas.1 Both of our groups have observed an association between vertical growth phase and sentinel node positivity in thin melanomas. Based on their earlier work,2,3 Drs. Roncati and Piscioli have proposed a histopathologic classification to guide clinical management, with sentinel lymph node biopsy recommended for subtypes of thin melanomas with a vertical growth phase or those with extensive regression, which may contain a vertical growth phase clone.4 Drs. Roncati and Piscioli suggest that thin melanomas with a vertical growth phase are generally of thickness greater than 0.8 mm and less than 1 mm, a subset of “thicker” thin melanomas more likely to result in a positive sentinel lymph node biopsy.5 Considered together, the implication is that the association between vertical growth phase and sentinel lymph node positivity may be driven by Breslow thickness. Although our meta-analysis confirms the observation that thin melanomas (defined as thickness >0.75 mm but <1.0 mm) are more likely to be associated with a positive sentinel lymph node biopsy, interestingly, we found that vertical growth phase was more strongly associated with sentinel lymph node positivity than Breslow thickness. Despite its seeming utility as a potential negative prognostic factor, vertical growth phase is not widely reported by dermatopathologists. Of the 93 studies included in our study, only seven studies reported on vertical growth phase. In contrast to other clinicopathologic features that can be measured and quantified (e.g., Breslow thickness and mitosis rate), vertical growth phase is less amenable to standardization.6 The fact that vertical growth phase is dependent on the experience and interpretation of individual pathologists is likely the greatest barrier to its wider adoption. The challenge of interpretation has previously been raised by Dr. Piscioli and colleagues in the context of atypical thin melanocytic lesions.7 Like Drs. Roncati and Piscioli, we feel that vertical growth phase is a histopathologic feature that may be used in addition to those outlined in the American Joint Committee on Cancer Staging Manual to identify a subset of aggressive thin melanomas. The utility of this histopathologic feature is, however, highly dependent on the experience and interpretation of dermatopathologists. When weighing the need for sentinel lymph node biopsy in a patient with a thin melanoma, communication between the treating surgeon and dermatopathologist is crucial. DISCLOSURE None of the authors has a financial interest to declare in relation to the content of this communication. Michael Bezuhly, F.R.C.S.C.Sarah E. Appleton, F.R.C.S.C.Zahir Fadel, M.D.Jason S. Williams, F.R.C.S.C.Division of Plastic and Reconstructive SurgeryDalhousie UniversityHalifax, Nova ScotiaDivision of Plastic and Reconstructive SurgeryMcMaster UniversityHamilton, Ontario, Canada" @default.
• W2997808550 created "2020-01-10" @default.
• W2997808550 creator A5019245718 @default.
• W2997808550 creator A5028124263 @default.
• W2997808550 creator A5054840359 @default.
• W2997808550 creator A5061698750 @default.
• W2997808550 date "2019-02-01" @default.
• W2997808550 modified "2023-10-18" @default.
• W2997808550 title "Reply" @default.
• W2997808550 cites W2520426194 @default.
• W2997808550 cites W2565825248 @default.
• W2997808550 cites W2625577553 @default.
• W2997808550 cites W2762347490 @default.
• W2997808550 cites W2902056486 @default.
• W2997808550 cites W42869079 @default.
• W2997808550 doi "https://doi.org/10.1097/prs.0000000000005243" @default.
• W2997808550 hasPublicationYear "2019" @default.
• W2997808550 type Work @default.
• W2997808550 sameAs 2997808550 @default.
• W2997808550 citedByCount "1" @default.
• W2997808550 countsByYear W29978085502022 @default.
• W2997808550 crossrefType "journal-article" @default.
• W2997808550 hasAuthorship W2997808550A5019245718 @default.
• W2997808550 hasAuthorship W2997808550A5028124263 @default.
• W2997808550 hasAuthorship W2997808550A5054840359 @default.
• W2997808550 hasAuthorship W2997808550A5061698750 @default.
• W2997808550 hasBestOaLocation W29978085501 @default.
• W2997808550 hasConcept C121608353 @default.
• W2997808550 hasConcept C126322002 @default.
• W2997808550 hasConcept C142724271 @default.
• W2997808550 hasConcept C179671157 @default.
• W2997808550 hasConcept C2775934546 @default.
• W2997808550 hasConcept C2779720271 @default.
• W2997808550 hasConcept C2780212769 @default.
• W2997808550 hasConcept C2780849966 @default.
• W2997808550 hasConcept C2908643394 @default.
• W2997808550 hasConcept C530470458 @default.
• W2997808550 hasConcept C71924100 @default.
• W2997808550 hasConceptScore W2997808550C121608353 @default.
• W2997808550 hasConceptScore W2997808550C126322002 @default.
• W2997808550 hasConceptScore W2997808550C142724271 @default.
• W2997808550 hasConceptScore W2997808550C179671157 @default.
• W2997808550 hasConceptScore W2997808550C2775934546 @default.
• W2997808550 hasConceptScore W2997808550C2779720271 @default.
• W2997808550 hasConceptScore W2997808550C2780212769 @default.
• W2997808550 hasConceptScore W2997808550C2780849966 @default.
• W2997808550 hasConceptScore W2997808550C2908643394 @default.
• W2997808550 hasConceptScore W2997808550C530470458 @default.
• W2997808550 hasConceptScore W2997808550C71924100 @default.
• W2997808550 hasIssue "2" @default.
• W2997808550 hasLocation W29978085501 @default.
• W2997808550 hasLocation W29978085502 @default.
• W2997808550 hasOpenAccess W2997808550 @default.
• W2997808550 hasPrimaryLocation W29978085501 @default.
• W2997808550 hasRelatedWork W136697608 @default.
• W2997808550 hasRelatedWork W1966798989 @default.
• W2997808550 hasRelatedWork W1973402430 @default.
• W2997808550 hasRelatedWork W2008553569 @default.
• W2997808550 hasRelatedWork W2020142317 @default.
• W2997808550 hasRelatedWork W2028414386 @default.
• W2997808550 hasRelatedWork W2896455132 @default.
• W2997808550 hasRelatedWork W2902441996 @default.
• W2997808550 hasRelatedWork W2942732466 @default.
• W2997808550 hasRelatedWork W4361257721 @default.
• W2997808550 hasVolume "143" @default.
• W2997808550 isParatext "false" @default.
• W2997808550 isRetracted "false" @default.
• W2997808550 magId "2997808550" @default.
• W2997808550 workType "article" @default.