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- W2997808712 abstract "Background: Acute renal failure is a serious early complication in patients with acute pancreatitis (AP) significantly increases mortality rates. Thus, it is essential to protect renal function in patients with severe AP. Methods: Acute necrotizing pancreatitis was induced by L-ornithine in 26 Wistar rats. 16 rats served as control. We administered enoxaparin in 10 rats after induction of acute pancreatitis during 5 days. The effect of enoxaparin was evaluated by determining the levels of serum amylase, creatinine, hydrogen sulfide, and fibrinogen, time of recalcification, activity of NO-synthase and myeloperoxidase (MPO) in pancreas. Results: The concentration of creatinine in serum is increase at 86.86%. It was noticed that the level of creatinine significantly directly correlated with the concentration of MPO and activity of iNOS in the pancreas, amylase in serum blood, and reverse with the concentration of H2S in serum. Renal failure in rats was accompanied by a hypercoagulation, determined by probable direct correlation between the levels of creatinine and fibrinogen, inverse relationship between creatinine concentrations and plasma recalcification time. Enoxaparin ameliorates morphology of the pancreas and kidney. The enoxaparin normalized serum creatinine, fibrinogen, amylase, MPO, H2S, decreased activity of iNOS. Conclusion: Enoxaparin in experimental AP reduces morphological signs of damage in the pancreas and kidneys, the intensity nitrosative stress and inflammation, normalizes hemostasis." @default.
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- W2997808712 date "2019-01-01" @default.
- W2997808712 modified "2023-09-30" @default.
- W2997808712 title "Protection of acute renal injury in severe experimental acute pancreatitis" @default.
- W2997808712 doi "https://doi.org/10.1016/j.hpb.2019.10.1521" @default.
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