Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997809575> ?p ?o ?g. }
- W2997809575 abstract "The hysteresis of keratinocyte (KC) re‑epithelialization is an important factor resulting in chronic wounds; however, the molecular mechanisms involved in this cellular response remain yet to be completely elucidated. The present study demonstrated the function of transcription factor Forkhead box O3a (FoxO3a) in KC growth and migration functional effects, resulting in restrained KC re‑epithelialization during wound healing. In chronic wound tissue samples, the expression of FoxO3a was significantly increased when compared with the acute wound healing group (P<0.01). Overexpressing FoxO3a significantly inhibited, whereas silencing endogenous FoxO3a enhanced, the growth and migration of HaCaT cells in vitro. Further investigation revealed that FoxO3a negatively regulated matrix metalloproteinases 1 and 9, and increased the expression of tissue inhibitor of metalloproteinase 1. In addition, the upregulation of FoxO3a retarded, whereas the downregulation of FoxO3a accelerated, transforming growth factor‑β1‑induced epithelial‑mesenchymal transition in HaCaT cells. Mechanistically, the overexpression of FoxO3a inactivated β‑catenin signaling and markedly reduced the levels of nuclear β‑catenin. These results reveal a novel mechanism of FoxO3a in regulating KC re‑epithelialization, and provide novel targets for the prevention and treatment of chronic wounds." @default.
- W2997809575 created "2020-01-10" @default.
- W2997809575 creator A5033431138 @default.
- W2997809575 creator A5054202651 @default.
- W2997809575 creator A5059857151 @default.
- W2997809575 creator A5072505266 @default.
- W2997809575 creator A5086118866 @default.
- W2997809575 date "2020-01-03" @default.
- W2997809575 modified "2023-09-27" @default.
- W2997809575 title "FoxO3a depletion accelerates cutaneous wound healing by regulating epithelial‑mesenchymal transition through β‑catenin activation" @default.
- W2997809575 cites W1573296762 @default.
- W2997809575 cites W1608217646 @default.
- W2997809575 cites W1826528130 @default.
- W2997809575 cites W1905763538 @default.
- W2997809575 cites W1977430213 @default.
- W2997809575 cites W2004098988 @default.
- W2997809575 cites W2008364361 @default.
- W2997809575 cites W2018489516 @default.
- W2997809575 cites W2022397532 @default.
- W2997809575 cites W2045232408 @default.
- W2997809575 cites W2060745257 @default.
- W2997809575 cites W2062570896 @default.
- W2997809575 cites W2072732760 @default.
- W2997809575 cites W2079505765 @default.
- W2997809575 cites W2092780583 @default.
- W2997809575 cites W2094030767 @default.
- W2997809575 cites W2098720608 @default.
- W2997809575 cites W2107277218 @default.
- W2997809575 cites W2147756339 @default.
- W2997809575 cites W2152773911 @default.
- W2997809575 cites W2217264961 @default.
- W2997809575 cites W2272204093 @default.
- W2997809575 cites W2294832903 @default.
- W2997809575 cites W2398488748 @default.
- W2997809575 cites W2440896068 @default.
- W2997809575 cites W2498125942 @default.
- W2997809575 cites W2501166301 @default.
- W2997809575 cites W2515028323 @default.
- W2997809575 cites W2527459561 @default.
- W2997809575 cites W2566399670 @default.
- W2997809575 cites W2568018505 @default.
- W2997809575 cites W2623353693 @default.
- W2997809575 cites W2735368216 @default.
- W2997809575 cites W2740755021 @default.
- W2997809575 cites W2742275673 @default.
- W2997809575 cites W2742501995 @default.
- W2997809575 cites W2765297119 @default.
- W2997809575 cites W2809122250 @default.
- W2997809575 cites W2884819597 @default.
- W2997809575 cites W2896169315 @default.
- W2997809575 cites W2900585188 @default.
- W2997809575 cites W2901159172 @default.
- W2997809575 doi "https://doi.org/10.3892/mmr.2020.10912" @default.
- W2997809575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7003051" @default.
- W2997809575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31922245" @default.
- W2997809575 hasPublicationYear "2020" @default.
- W2997809575 type Work @default.
- W2997809575 sameAs 2997809575 @default.
- W2997809575 citedByCount "2" @default.
- W2997809575 countsByYear W29978095752021 @default.
- W2997809575 countsByYear W29978095752023 @default.
- W2997809575 crossrefType "journal-article" @default.
- W2997809575 hasAuthorship W2997809575A5033431138 @default.
- W2997809575 hasAuthorship W2997809575A5054202651 @default.
- W2997809575 hasAuthorship W2997809575A5059857151 @default.
- W2997809575 hasAuthorship W2997809575A5072505266 @default.
- W2997809575 hasAuthorship W2997809575A5086118866 @default.
- W2997809575 hasBestOaLocation W29978095751 @default.
- W2997809575 hasConcept C104317684 @default.
- W2997809575 hasConcept C109523444 @default.
- W2997809575 hasConcept C118131993 @default.
- W2997809575 hasConcept C118995209 @default.
- W2997809575 hasConcept C119056186 @default.
- W2997809575 hasConcept C127561419 @default.
- W2997809575 hasConcept C137620995 @default.
- W2997809575 hasConcept C170493617 @default.
- W2997809575 hasConcept C185592680 @default.
- W2997809575 hasConcept C190283241 @default.
- W2997809575 hasConcept C202751555 @default.
- W2997809575 hasConcept C203014093 @default.
- W2997809575 hasConcept C2775960820 @default.
- W2997809575 hasConcept C2777074287 @default.
- W2997809575 hasConcept C2778615670 @default.
- W2997809575 hasConcept C2780269544 @default.
- W2997809575 hasConcept C2781018059 @default.
- W2997809575 hasConcept C29537977 @default.
- W2997809575 hasConcept C30145163 @default.
- W2997809575 hasConcept C502942594 @default.
- W2997809575 hasConcept C55493867 @default.
- W2997809575 hasConcept C62112901 @default.
- W2997809575 hasConcept C62478195 @default.
- W2997809575 hasConcept C76419328 @default.
- W2997809575 hasConcept C86803240 @default.
- W2997809575 hasConcept C95444343 @default.
- W2997809575 hasConceptScore W2997809575C104317684 @default.
- W2997809575 hasConceptScore W2997809575C109523444 @default.
- W2997809575 hasConceptScore W2997809575C118131993 @default.
- W2997809575 hasConceptScore W2997809575C118995209 @default.
- W2997809575 hasConceptScore W2997809575C119056186 @default.
- W2997809575 hasConceptScore W2997809575C127561419 @default.