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• W2997889683 abstract "Novel 3,5-dimethylpyridin-4(1H)-one scaffold compounds were synthesized and evaluated as AMP-activated protein kinase (AMPK) activators. Unlike direct AMPK activators, this series of compounds showed selective cell growth inhibitory activity against human breast cancer cell lines. By optimizing the lead compound (4a) from our library, 2-[({1'-[(4-fluorophenyl)methyl]-2-methyl-1',2',3',6'-tetrahydro[3,4'-bipyridin]-6-yl}oxy)methyl]-3,5-dimethylpyridin-4(1H)-one (25) was found to have potent AMPK activating activity. Compound 25 also showed good aqueous solubility while maintaining the unique selectivity in cell growth inhibitory activity." @default.
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• W2997889683 date "2020-01-01" @default.
• W2997889683 modified "2023-10-16" @default.
• W2997889683 title "Discovery of 3,5-Dimethylpyridin-4(1<i>H</i>)-one Derivatives as Activators of AMP-Activated Protein Kinase (AMPK)" @default.
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• W2997889683 doi "https://doi.org/10.1248/cpb.c19-00800" @default.
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