FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997901286> ?p ?o ?g. }

• W2997901286 abstract "Thyroid hormones (THs) are critically important for development, homeostasis, and metabolic regulation in mammals. Iodine, one of the constituents of TH, is actively supplied by sodium iodide symporter (NIS) into the thyroid gland. TH is subsequently transported to distant organs where its activation and deactivation is catalyzed by isoforms of deiodinases (DIOs). NIS protein has been known to overexpress in cancer cases of the breast and gastrointestinal organs. Recent studies show a possible role of DIOs in various cancers.In the present investigation, the prognostic significance of NIS and DIO-1, 2 and 3 was studied in gastric cancer using a data mining bioinformatic approach.The Kaplan-Meier plotter database was used for direct in silico validation in clinically relevant 876 gastric cancer patients with >15 years of follow-up information. After obtaining KM survival plots, hazard ratio and log-rank P value were calculated.Increased expression of NIS and DIO 1-3 is significantly associated with worsen overall survival of gastric cancer patients followed for 20 years. Prognostic roles of NIS and individual DIOs were assessed in different types of gastric cancer classified based on morphologies, human epidermal growth factor receptor-2 receptor status, treatment choices, and different clinicopathological features.Based on these analyses, the present study found the indication of prognostic values of these genes. This information will contribute to better understanding of managing complex and heterogeneous gastric cancer. Further, these findings may be beneficial as a companion diagnostic tool predicting more accurate gastric cancer prognosis." @default.
• W2997901286 created "2020-01-10" @default.
• W2997901286 creator A5059230101 @default.
• W2997901286 creator A5081241139 @default.
• W2997901286 date "2020-01-01" @default.
• W2997901286 modified "2023-10-17" @default.
• W2997901286 title "Prognostic significance of sodium iodide symporter and deiodinase enzymes mRNA expression in gastric cancer" @default.
• W2997901286 cites W1757407923 @default.
• W2997901286 cites W182569639 @default.
• W2997901286 cites W1970372358 @default.
• W2997901286 cites W1972878113 @default.
• W2997901286 cites W1974507941 @default.
• W2997901286 cites W1976074184 @default.
• W2997901286 cites W1989682006 @default.
• W2997901286 cites W1994192984 @default.
• W2997901286 cites W1994594485 @default.
• W2997901286 cites W1999967639 @default.
• W2997901286 cites W2000377989 @default.
• W2997901286 cites W2031011739 @default.
• W2997901286 cites W2033393264 @default.
• W2997901286 cites W2034083247 @default.
• W2997901286 cites W2043405039 @default.
• W2997901286 cites W2052131061 @default.
• W2997901286 cites W2054826101 @default.
• W2997901286 cites W2059755429 @default.
• W2997901286 cites W2063665939 @default.
• W2997901286 cites W2065927601 @default.
• W2997901286 cites W207349744 @default.
• W2997901286 cites W2091590087 @default.
• W2997901286 cites W2101514909 @default.
• W2997901286 cites W2106787323 @default.
• W2997901286 cites W2147545451 @default.
• W2997901286 cites W2160024384 @default.
• W2997901286 cites W2168202113 @default.
• W2997901286 cites W2203121312 @default.
• W2997901286 cites W2318017892 @default.
• W2997901286 cites W2463600666 @default.
• W2997901286 cites W2737785069 @default.
• W2997901286 cites W2804728815 @default.
• W2997901286 cites W2890116952 @default.
• W2997901286 cites W6101777 @default.
• W2997901286 cites W2031832508 @default.
• W2997901286 doi "https://doi.org/10.4103/ijabmr.ijabmr_287_19" @default.
• W2997901286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6967347" @default.
• W2997901286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32002385" @default.
• W2997901286 hasPublicationYear "2020" @default.
• W2997901286 type Work @default.
• W2997901286 sameAs 2997901286 @default.
• W2997901286 citedByCount "3" @default.
• W2997901286 countsByYear W29979012862021 @default.
• W2997901286 crossrefType "journal-article" @default.
• W2997901286 hasAuthorship W2997901286A5059230101 @default.
• W2997901286 hasAuthorship W2997901286A5081241139 @default.
• W2997901286 hasBestOaLocation W29979012862 @default.
• W2997901286 hasConcept C104317684 @default.
• W2997901286 hasConcept C120405084 @default.
• W2997901286 hasConcept C121608353 @default.
• W2997901286 hasConcept C126322002 @default.
• W2997901286 hasConcept C134018914 @default.
• W2997901286 hasConcept C143998085 @default.
• W2997901286 hasConcept C149011108 @default.
• W2997901286 hasConcept C207103383 @default.
• W2997901286 hasConcept C2778288131 @default.
• W2997901286 hasConcept C2778417266 @default.
• W2997901286 hasConcept C2779761222 @default.
• W2997901286 hasConcept C2780616701 @default.
• W2997901286 hasConcept C44249647 @default.
• W2997901286 hasConcept C502942594 @default.
• W2997901286 hasConcept C526584372 @default.
• W2997901286 hasConcept C55493867 @default.
• W2997901286 hasConcept C71924100 @default.
• W2997901286 hasConcept C86803240 @default.
• W2997901286 hasConceptScore W2997901286C104317684 @default.
• W2997901286 hasConceptScore W2997901286C120405084 @default.
• W2997901286 hasConceptScore W2997901286C121608353 @default.
• W2997901286 hasConceptScore W2997901286C126322002 @default.
• W2997901286 hasConceptScore W2997901286C134018914 @default.
• W2997901286 hasConceptScore W2997901286C143998085 @default.
• W2997901286 hasConceptScore W2997901286C149011108 @default.
• W2997901286 hasConceptScore W2997901286C207103383 @default.
• W2997901286 hasConceptScore W2997901286C2778288131 @default.
• W2997901286 hasConceptScore W2997901286C2778417266 @default.
• W2997901286 hasConceptScore W2997901286C2779761222 @default.
• W2997901286 hasConceptScore W2997901286C2780616701 @default.
• W2997901286 hasConceptScore W2997901286C44249647 @default.
• W2997901286 hasConceptScore W2997901286C502942594 @default.
• W2997901286 hasConceptScore W2997901286C526584372 @default.
• W2997901286 hasConceptScore W2997901286C55493867 @default.
• W2997901286 hasConceptScore W2997901286C71924100 @default.
• W2997901286 hasConceptScore W2997901286C86803240 @default.
• W2997901286 hasLocation W29979012861 @default.
• W2997901286 hasLocation W29979012862 @default.
• W2997901286 hasLocation W29979012863 @default.
• W2997901286 hasLocation W29979012864 @default.
• W2997901286 hasOpenAccess W2997901286 @default.
• W2997901286 hasPrimaryLocation W29979012861 @default.
• W2997901286 hasRelatedWork W10149858 @default.
• W2997901286 hasRelatedWork W10925770 @default.
• W2997901286 hasRelatedWork W11097087 @default.
• W2997901286 hasRelatedWork W1113127 @default.

• next