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- W2997951819 endingPage "111079" @default.
- W2997951819 startingPage "111079" @default.
- W2997951819 abstract "Cisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. Cisplatin induces ototoxicity, peripheral (most prevalent) and central (rare) neurotoxicity. This review addresses the ototoxicity and the neurotoxicity associated with cisplatin-based chemotherapy, providing an integrated view of the potential protective agents that have been evaluated in vitro, in vivo and in clinical trials, their targets and mechanisms of protection and their effects on the antitumor activity of cisplatin. So far, the findings are insufficient to support the use of any oto- or neuroprotective agent before, during or after cisplatin chemotherapy. Despite their promising effects in vitro and in animal studies, many agents have not been evaluated in clinical trials. Additionally, the clinical trials have limitations concerning the sample size, controls, measurement, heterogeneous groups, several arms of treatment, short follow-up or no blinding. Besides that, for most agents, the effects on the antitumor activity of cisplatin have not been evaluated in tumor-bearing animals, which discourages clinical trials. Further well-designed randomized controlled clinical trials are necessary to definitely demonstrate the effectiveness of the oto- or neuroprotective agents proposed by animal and in vitro studies." @default.
- W2997951819 created "2020-01-10" @default.
- W2997951819 creator A5016175068 @default.
- W2997951819 creator A5076291801 @default.
- W2997951819 creator A5082536572 @default.
- W2997951819 date "2020-02-01" @default.
- W2997951819 modified "2023-10-11" @default.
- W2997951819 title "Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents" @default.
- W2997951819 cites W102427289 @default.
- W2997951819 cites W1128519461 @default.
- W2997951819 cites W1240888426 @default.
- W2997951819 cites W141235770 @default.
- W2997951819 cites W1480285457 @default.
- W2997951819 cites W1521106297 @default.
- W2997951819 cites W1541295483 @default.
- W2997951819 cites W1547601417 @default.
- W2997951819 cites W1552461420 @default.
- W2997951819 cites W1553483712 @default.
- W2997951819 cites W1587984613 @default.
- W2997951819 cites W1598593661 @default.
- W2997951819 cites W1755671302 @default.
- W2997951819 cites W1808995917 @default.
- W2997951819 cites W1832113570 @default.
- W2997951819 cites W1887408233 @default.
- W2997951819 cites W1963701508 @default.
- W2997951819 cites W1964180629 @default.
- W2997951819 cites W1965721489 @default.
- W2997951819 cites W1965975698 @default.
- W2997951819 cites W1966110021 @default.
- W2997951819 cites W1971168416 @default.
- W2997951819 cites W1972237278 @default.
- W2997951819 cites W1973967984 @default.
- W2997951819 cites W1974049018 @default.
- W2997951819 cites W1974595904 @default.
- W2997951819 cites W1974693247 @default.
- W2997951819 cites W1975659607 @default.
- W2997951819 cites W1976879608 @default.
- W2997951819 cites W1978127809 @default.
- W2997951819 cites W1978198695 @default.
- W2997951819 cites W1979796591 @default.
- W2997951819 cites W1980399979 @default.
- W2997951819 cites W1980411311 @default.
- W2997951819 cites W1980505253 @default.
- W2997951819 cites W1985091470 @default.
- W2997951819 cites W1986312380 @default.
- W2997951819 cites W1988224167 @default.
- W2997951819 cites W1988987752 @default.
- W2997951819 cites W1989445499 @default.
- W2997951819 cites W1989450539 @default.
- W2997951819 cites W1990582908 @default.
- W2997951819 cites W1992121983 @default.
- W2997951819 cites W1992820423 @default.
- W2997951819 cites W1993397541 @default.
- W2997951819 cites W1996111334 @default.
- W2997951819 cites W1996363103 @default.
- W2997951819 cites W1996740623 @default.
- W2997951819 cites W1997440309 @default.
- W2997951819 cites W1998147719 @default.
- W2997951819 cites W1998784857 @default.
- W2997951819 cites W2000297826 @default.
- W2997951819 cites W2000717219 @default.
- W2997951819 cites W2001578391 @default.
- W2997951819 cites W2002418060 @default.
- W2997951819 cites W2006083013 @default.
- W2997951819 cites W2006376003 @default.
- W2997951819 cites W2006516099 @default.
- W2997951819 cites W2007302872 @default.
- W2997951819 cites W2009338130 @default.
- W2997951819 cites W2009929398 @default.
- W2997951819 cites W2012108057 @default.
- W2997951819 cites W2014699854 @default.
- W2997951819 cites W2015831774 @default.
- W2997951819 cites W2016347526 @default.
- W2997951819 cites W2017339977 @default.
- W2997951819 cites W2017753045 @default.
- W2997951819 cites W2022520035 @default.
- W2997951819 cites W2023111282 @default.
- W2997951819 cites W2023670367 @default.
- W2997951819 cites W2023770379 @default.
- W2997951819 cites W2023822056 @default.
- W2997951819 cites W2024375371 @default.
- W2997951819 cites W2025062165 @default.
- W2997951819 cites W2025527455 @default.
- W2997951819 cites W2030152831 @default.
- W2997951819 cites W2030455306 @default.
- W2997951819 cites W2030805195 @default.
- W2997951819 cites W2032268538 @default.
- W2997951819 cites W2032330037 @default.
- W2997951819 cites W2033005746 @default.
- W2997951819 cites W2034664046 @default.
- W2997951819 cites W2035598226 @default.
- W2997951819 cites W2035889265 @default.
- W2997951819 cites W2036489897 @default.
- W2997951819 cites W2037439350 @default.
- W2997951819 cites W2037682503 @default.
- W2997951819 cites W2038125912 @default.
- W2997951819 cites W2038258886 @default.
- W2997951819 cites W2040841210 @default.