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• W2998014741 abstract "Tak-242 (resatorvid), a Toll-like Receptor 4 (TLR4) inhibitor, has been identified as a potent suppressor of innate inflammation. As a strategy to target Tak-242 to select tissue, four TLR4-inactive prodrugs were synthesized for activation via two different release mechanisms. Two nitrobenzyl Tak-242 prodrugs released the parent drug upon exposure to the exogenous enzyme nitroreductase, while the two propargyl prodrugs were converted to Tak-242 in the presence of Pd0." @default.
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• W2998014741 date "2020-01-03" @default.
• W2998014741 modified "2023-10-01" @default.
• W2998014741 title "Design and Catalyzed Activation of Tak-242 Prodrugs for Localized Inhibition of TLR4-Induced Inflammation" @default.
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• W2998014741 doi "https://doi.org/10.1021/acsmedchemlett.9b00518" @default.
• W2998014741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7025376" @default.
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