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• W2998045348 endingPage "e0227095" @default.
• W2998045348 startingPage "e0227095" @default.
• W2998045348 abstract "We hypothesized that heat-induced perturbations in cumulus cells surrounding the maturing oocyte may extend to the mural granulosa of the periovulatory follicle in the heat-stressed cow to subsequently the follicular fluid proteome. Lactating Holsteins were pharmacologically stimulated to have a dominant follicle that was capable of responding to a gonadotropin releasing hormone-induced luteinizing hormone surge. Following gonadotropin releasing hormone administration, cows were maintained at ~67 temperature humidity index (THI; thermoneutral conditions) or exposed to conditions simulating an acute heat stress event (71 to 86 THI; heat stress for ~12 h). Dominant follicle collection was conducted in the periovulatory period ~16 h after gonadotropin releasing hormone. Follicular fluid proteome from thermoneutral (n = 5) and hyperthermic (n = 5) cows was evaluated by quantitative tandem mass spectrometry (nano LC-MS/MS). We identified 35 differentially-abundant proteins. Functional annotation revealed numerous immune-related proteins. Subsequent efforts revealed an increase in levels of the proinflammatory mediator bradykinin in follicular fluid (P = 0.0456) but not in serum (P = 0.9319) of hyperthermic cows. Intrafollicular increases in transferrin (negative acute phase protein) in hyperthermic cows (P = 0.0181) coincided with a tendency for levels to be increased in the circulation (P = 0.0683). Nine out of 15 cytokines evaluated were detected in follicular fluid. Heat stress increased intrafollicular interleukin 6 levels (P = 0.0160). Whether hyperthermia-induced changes in the heat-stressed cow’s follicular fluid milieu reflect changes in mural granulosa, cumulus, other cell types secretions, and/or transudative changes from circulation remains unclear. Regardless of origin, heat stress/hyperthermia related changes in the follicular fluid milieu may have an impact on components important for ovulation and competence of the cumulus-oocyte complex contained within the periovulatory follicle." @default.
• W2998045348 created "2020-01-10" @default.
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• W2998045348 date "2019-12-30" @default.
• W2998045348 modified "2023-10-01" @default.
• W2998045348 title "Heat-induced hyperthermia impacts the follicular fluid proteome of the periovulatory follicle in lactating dairy cows" @default.
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• W2998045348 doi "https://doi.org/10.1371/journal.pone.0227095" @default.
• W2998045348 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6936800" @default.
• W2998045348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31887207" @default.
• W2998045348 hasPublicationYear "2019" @default.
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