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- W2998052256 abstract "To develop and validate a non-invasive method for the prediction of congenital CMV infection after primary maternal CMV infection. Secondary analysis of a multicenter randomized placebo controlled trial of CMV hyperimmune globulin to prevent congenital CMV infection. Women were eligible if they had primary CMV infection, defined as positive IgM antibody and IgG antibody with avidity < 50% before 24 weeks or IgG seroconversion before 28 weeks, and were carrying a singleton fetus without ultrasound findings suspicious for CMV infection. Antibody assay was performed in a single reference laboratory. Congenital infection was defined as CMV detection in amniotic fluid, neonatal urine or saliva, or post-mortem tissue. Using backward elimination, we developed a logit model for prediction of congenital infection from factors known at randomization. Factors included maternal age, parity, race, ethnicity, BMI, children at home, gestational age at serologic testing, IgM antibody index≥4.5, IgG avidity < 32%, and treatment group. The performance of the model was assessed using leave-1-out cross validation (a method of internal validation). 399 women were randomized and 362 had informative data for this analysis. The primary outcome occurred in 71 (20%). The final model (Table) included black race (yes/no), IgM ≥4.5 (yes/no) and IgG avidity < 32% (yes/no). Cross validation showed an average AUC of 0.71(95% CI 0.65-0.78), indicating moderate discriminatory ability. Examples of prediction: For a black woman with avidity < 32% and IgM≥4.5, probability of congenital infection = 0.75 (0.58-0.86); for a non-black woman with avidity ≥32% and IgM< 4.5, probability of infection = 0.04 (0.02-0.08). We developed and validated a model that may be useful for decision making in the face of primary maternal CMV infection and absence of ultrasound findings suspicious for CMV infection." @default.
- W2998052256 created "2020-01-10" @default.
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- W2998052256 date "2020-01-01" @default.
- W2998052256 modified "2023-09-25" @default.
- W2998052256 title "267: Non-invasive prediction of congenital cytomegalovirus (CMV) infection after maternal primary infection" @default.
- W2998052256 doi "https://doi.org/10.1016/j.ajog.2019.11.283" @default.
- W2998052256 hasPublicationYear "2020" @default.
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