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- W2998063978 abstract "Background: RAS mutation status is an important prognostic factor after complete liver resection for colorectal cancer metastasis (LiM). Objective: To evaluate the impact of RAS status on survival after potentially curative resection for lung (LuM) and peritoneal (PM) metastases from metastatic colorectal cancer. Methods: Between 2005 and 2014, all consecutive patients with known RAS status who underwent curative resection for LiM, LuM, or PM were evaluated. Recurrence pattern was evaluated for all patients who had a known status 18 months after surgery. Results: All 720 patients operated on for unique metastatic sites, 468(65%), 102(14%) and 150(21%) presented with LiM, LuM and PM, respectively. RAS mutation was significantly less frequent for LiM (41% LiM, 64% LuM, 58% PM; p<0.001). Five-year overall survival (OS) was 52%, 63% and 45% for LiM, LuM and PM, respectively. PM presented a significantly worse OS than LiM and LuM (p=0.023; p=0.006, respectively). OS was significantly better for patients RAS wild type for LiM (p<0.001), but no difference in OS was observed regarding RAS status for LuM and PM (p=0.412; p=0.650, respectively). For each metastatic site the risk of recurrence was higher site itself, but there was not difference for recurrence based on RAS status. Conclusion: Surgical resection of LiM, LuM and PM associated with systemic chemotherapy provide long term survival. RAS mutation status represents a prognostic factor after metastasis resection only for LiM." @default.
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- W2998063978 date "2019-01-01" @default.
- W2998063978 modified "2023-09-30" @default.
- W2998063978 title "RAS mutation for metastatic colorectal cancer treated with potentially curative intent: impact of metastasis site." @default.
- W2998063978 doi "https://doi.org/10.1016/j.hpb.2019.10.1223" @default.
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