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- W2998074414 endingPage "105684" @default.
- W2998074414 startingPage "105684" @default.
- W2998074414 abstract "During the growing process of the atherosclerotic lesions, lipid-filled macrophage foam cells form, accumulate, and ultimately undergo apoptotic death. If the apoptotic foam cells are not timely removed, they may undergo secondary necrosis, and form a necrotic lipid core which renders the plaque unstable and susceptible to rupture. Therefore, the non-lipid-filled fellow macrophages, as the main phagocytic cells in atherosclerotic lesions, need to effectively remove the apoptotic foam cells. In general, in apoptotic macrophages, caspases are the central regulators of several key processes required for their efficient efferocytosis. The processes include the generation of “Find-Me” signals (such as adenosine triphosphate/uridine triphosphate, fractalkine, lysophosphatidylcholine, and sphingosine-1-phosphate) for the recruitment of viable macrophages, generation of the Eat-Me signals (for example, phosphatidylserine) for the engulfment process, and, finally, release of anti-inflammatory mediators (including transforming factor β and interleukin-10) as a tolerance-enhancing and an anti-inflammatory response, and for the motile behavior of the apoptotic cell. The caspase-dependent mechanisms are operative also in apoptotic macrophages driving the atherogenesis. In this review, we explore the role of the molecular pathways related to the caspase-dependent events in efferocytosis in the context of atherosclerosis. Understanding of the molecular mechanisms of apoptotic cell death in atherosclerotic lesions is essential when searching for new leads to treat atherosclerosis." @default.
- W2998074414 created "2020-01-10" @default.
- W2998074414 creator A5033507359 @default.
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- W2998074414 creator A5053191492 @default.
- W2998074414 creator A5060135294 @default.
- W2998074414 creator A5085875890 @default.
- W2998074414 date "2020-03-01" @default.
- W2998074414 modified "2023-09-25" @default.
- W2998074414 title "Regulation of efferocytosis by caspase-dependent apoptotic cell death in atherosclerosis" @default.
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