FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998081307> ?p ?o ?g. }

• W2998081307 endingPage "1625" @default.
• W2998081307 startingPage "1613" @default.
• W2998081307 abstract "The introduction of BCR-ABL tyrosine kinase inhibitors has revolutionized the treatment of chronic myeloid leukemia (CML). A major clinical aim remains the identification and elimination of low-level disease persistence, termed minimal residual disease. The phenomenon of disease persistence suggests that despite targeted therapeutic approaches, BCR-ABL-independent mechanisms exist which sustain the survival of leukemic stem cells (LSCs). Although other markers of a primitive CML LSC population have been identified in the preclinical setting, only CD26 appears to offer clinical utility. Here we demonstrate consistent and selective expression of CD93 on a lin-CD34+CD38-CD90+ CML LSC population and show in vitro and in vivo data to suggest increased stem cell characteristics, as well as robust engraftment in patient-derived xenograft models in comparison with a CD93- CML stem/progenitor cell population, which fails to engraft. Through bulk and single-cell analyses of selected stem cell and cell survival-specific genes, we confirmed the quiescent character and demonstrate their persistence in a population of CML patient samples who demonstrate molecular relapse on TKI withdrawal. Taken together, our results identify that CD93 is consistently and selectively expressed on a lin-CD34+CD38-CD90+ CML LSC population with stem cell characteristics and may be an important indicator in determining poor TKI responders." @default.
• W2998081307 created "2020-01-10" @default.
• W2998081307 creator A5009607061 @default.
• W2998081307 creator A5011733008 @default.
• W2998081307 creator A5014762019 @default.
• W2998081307 creator A5030027209 @default.
• W2998081307 creator A5032156036 @default.
• W2998081307 creator A5035887338 @default.
• W2998081307 creator A5045823910 @default.
• W2998081307 creator A5045828108 @default.
• W2998081307 creator A5047732858 @default.
• W2998081307 creator A5050908023 @default.
• W2998081307 creator A5057534414 @default.
• W2998081307 creator A5069956148 @default.
• W2998081307 creator A5072637924 @default.
• W2998081307 creator A5081213425 @default.
• W2998081307 creator A5081853382 @default.
• W2998081307 creator A5084024554 @default.
• W2998081307 date "2020-01-02" @default.
• W2998081307 modified "2023-10-14" @default.
• W2998081307 title "CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy" @default.
• W2998081307 cites W120597284 @default.
• W2998081307 cites W1532045650 @default.
• W2998081307 cites W1841276786 @default.
• W2998081307 cites W1979050260 @default.
• W2998081307 cites W1986422421 @default.
• W2998081307 cites W1987239635 @default.
• W2998081307 cites W1991627484 @default.
• W2998081307 cites W2006711239 @default.
• W2998081307 cites W2018279800 @default.
• W2998081307 cites W2020526785 @default.
• W2998081307 cites W2025329130 @default.
• W2998081307 cites W2035287163 @default.
• W2998081307 cites W2036267284 @default.
• W2998081307 cites W2041004587 @default.
• W2998081307 cites W2050184823 @default.
• W2998081307 cites W2062317197 @default.
• W2998081307 cites W2081098333 @default.
• W2998081307 cites W2107277218 @default.
• W2998081307 cites W2112817157 @default.
• W2998081307 cites W2113081116 @default.
• W2998081307 cites W2113752195 @default.
• W2998081307 cites W2122224021 @default.
• W2998081307 cites W2137460766 @default.
• W2998081307 cites W2146512944 @default.
• W2998081307 cites W2146860878 @default.
• W2998081307 cites W2149468947 @default.
• W2998081307 cites W2177783313 @default.
• W2998081307 cites W2343680173 @default.
• W2998081307 cites W2412914653 @default.
• W2998081307 cites W2519273869 @default.
• W2998081307 cites W2520339276 @default.
• W2998081307 cites W2580232087 @default.
• W2998081307 cites W2763035609 @default.
• W2998081307 cites W2803169439 @default.
• W2998081307 cites W2805227060 @default.
• W2998081307 cites W2912432460 @default.
• W2998081307 cites W2952885451 @default.
• W2998081307 cites W86828126 @default.
• W2998081307 doi "https://doi.org/10.1038/s41375-019-0684-5" @default.
• W2998081307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8076018" @default.
• W2998081307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32005922" @default.
• W2998081307 hasPublicationYear "2020" @default.
• W2998081307 type Work @default.
• W2998081307 sameAs 2998081307 @default.
• W2998081307 citedByCount "38" @default.
• W2998081307 countsByYear W29980813072019 @default.
• W2998081307 countsByYear W29980813072020 @default.
• W2998081307 countsByYear W29980813072021 @default.
• W2998081307 countsByYear W29980813072022 @default.
• W2998081307 countsByYear W29980813072023 @default.
• W2998081307 crossrefType "journal-article" @default.
• W2998081307 hasAuthorship W2998081307A5009607061 @default.
• W2998081307 hasAuthorship W2998081307A5011733008 @default.
• W2998081307 hasAuthorship W2998081307A5014762019 @default.
• W2998081307 hasAuthorship W2998081307A5030027209 @default.
• W2998081307 hasAuthorship W2998081307A5032156036 @default.
• W2998081307 hasAuthorship W2998081307A5035887338 @default.
• W2998081307 hasAuthorship W2998081307A5045823910 @default.
• W2998081307 hasAuthorship W2998081307A5045828108 @default.
• W2998081307 hasAuthorship W2998081307A5047732858 @default.
• W2998081307 hasAuthorship W2998081307A5050908023 @default.
• W2998081307 hasAuthorship W2998081307A5057534414 @default.
• W2998081307 hasAuthorship W2998081307A5069956148 @default.
• W2998081307 hasAuthorship W2998081307A5072637924 @default.
• W2998081307 hasAuthorship W2998081307A5081213425 @default.
• W2998081307 hasAuthorship W2998081307A5081853382 @default.
• W2998081307 hasAuthorship W2998081307A5084024554 @default.
• W2998081307 hasBestOaLocation W29980813071 @default.
• W2998081307 hasConcept C10205521 @default.
• W2998081307 hasConcept C116716535 @default.
• W2998081307 hasConcept C159912055 @default.
• W2998081307 hasConcept C201750760 @default.
• W2998081307 hasConcept C203014093 @default.
• W2998081307 hasConcept C2778461978 @default.
• W2998081307 hasConcept C2778729363 @default.
• W2998081307 hasConcept C2779282312 @default.
• W2998081307 hasConcept C2779823535 @default.

• next