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- W2998092780 abstract "Biocompatible platforms, wherein cells attach and grow, are important for controlling cytoskeletal dynamics and steering stem cell functions, including differentiation. Among various components, membrane integrins play a key role in focal adhesion of cells (18-20 nm in size) and are, thus, highly sensitive to the nanotopographical features of underlying substrates. Hence, it is necessary to develop a platform/technique that can provide high flexibility in controlling nanostructure sizes. We report a platform modified with homogeneous nanohole patterns, effective in guiding neurogenesis of mouse neural stem cells (mNSCs). Sizes of nanoholes were easily generated and varied using laser interference lithography (LIL), by changing the incident angles of light interference on substrates. Among three different nanohole patterns fabricated on conductive transparent electrodes, 500 nm-sized nanoholes showed the best performance for cell adhesion and spreading, based on F-actin and lamellipodia/filopodia expression. Enhanced biocompatibility and cell adhesion of these nanohole patterns ultimately resulted in the enhanced neurogenesis of mNSCs, based on the mRNAs expression level of the mNSCs marker and several neuronal markers. Therefore, platforms modified with homogeneous nanohole patterns fabricated by LIL are promising for the precise tuning of nanostructures in tissue culture platforms and useful for controlling various differentiation lineages of stem cells." @default.
- W2998092780 created "2020-01-10" @default.
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- W2998092780 date "2019-12-26" @default.
- W2998092780 modified "2023-09-23" @default.
- W2998092780 title "Enhancing Neurogenesis of Neural Stem Cells Using Homogeneous Nanohole Pattern-Modified Conductive Platform" @default.
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- W2998092780 doi "https://doi.org/10.3390/ijms21010191" @default.
- W2998092780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6981825" @default.
- W2998092780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31888101" @default.
- W2998092780 hasPublicationYear "2019" @default.
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