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• W2998098016 abstract "This chapter describes the history of laboratory mice; the types of mouse strains available; the handling of mouse colonies, mouse cell lines, and strains; and the use of mouse models in preclinical studies. A variety of mouse models have been generated, and this will likely be accelerated by the sequencing of the mouse genome. The World Wide Web offers information on the mouse strains available to the research community. The International Mouse Strain Resource website is a searchable online database of international repositories of mouse strains and mutant embryonic stem cell lines, including inbred, spontaneous mutant, and genetically engineered strains. Animal models have increasingly become the preferred tool in research on mechanisms of pathogenesis, drug discovery, and translational studies. The chapter introduces the recent concept of incorporating patient-derived models into the drug discovery process, from target to clinical development." @default.
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• W2998098016 date "2019-12-27" @default.
• W2998098016 modified "2023-09-28" @default.
• W2998098016 title "Summary of Currently Available Mouse Models" @default.
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• W2998098016 doi "https://doi.org/10.1002/9783527344406.ch1" @default.
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