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- W2998167466 abstract "Due to high programmability and good biocompatibility, DNA has been recognized as a powerful building block for engineering of sophisticated nanostructures for different purposes. Herein, we present the first example of a bead-string-shaped DNA nanowire (BS-nanow) with long-range structural order for in vivo bioimaging and targeted drug delivery. BS-nanow is assembled from DNA tetrahedron units with precise nanometer-scale spatial control, capable of accommodating chemotherapeutic agents with high payload capacity (1204 binding sites) as well as possessing a 60-fold enhanced binding affinity for target cells. Confocal fluorescence imaging and in vivo experiments on CEM subcutaneous tumor-bearing mice show that specific bioimaging of living cells and even systemic delivery of drugs into internal tumor organs and tissues were accomplished, thereby achieving an efficient inhibition of tumor growth in the xenograft model without systemic toxicity. BS-nanow's show potential in vivo applications in accurate diagnosis and targeted therapy for human cancer." @default.
- W2998167466 created "2020-01-10" @default.
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- W2998167466 date "2019-12-27" @default.
- W2998167466 modified "2023-10-06" @default.
- W2998167466 title "Bead-String-Shaped DNA Nanowires with Intrinsic Structural Advantages and Their Potential for Biomedical Applications" @default.
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- W2998167466 doi "https://doi.org/10.1021/acsami.9b16249" @default.
- W2998167466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31878778" @default.
- W2998167466 hasPublicationYear "2019" @default.
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