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• W2998238363 abstract "One specific technological advance in transdermal drug delivery is the development of dissolving microneedles (DMNs), which efficiently deliver therapeutics through a rapid dissolution of polymers after penetration into the skin. However, there is a limited range of water soluble, biodegradable polymers that can be used to manufacture DMN. Here, we report for the first time, the preparation and characterisation of a DMN system from the carbohydrate biopolymer, pullulan (PL). PL gels, of varying concentration, were studied for viscosity, film formation properties, and subsequently, microneedle formation. Model molecules and protein/peptide were loaded into PL DMN and characterised. The stability of model biomolecules, such as FITC-BSA and insulin, following DMN manufacture were assessed using circular dichroism. Ex-vivo porcine skin permeation studies using Franz diffusion cell apparatus for Flu-Na and FITC-BSA loaded PL-DMN were conducted. This study demonstrates that PL DMNs may serve as a promising tool for efficient transdermal drug delivery." @default.
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• W2998238363 date "2020-03-01" @default.
• W2998238363 modified "2023-10-06" @default.
• W2998238363 title "Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules" @default.
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• W2998238363 doi "https://doi.org/10.1016/j.ijbiomac.2019.12.184" @default.
• W2998238363 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7031695" @default.
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