FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998264310> ?p ?o ?g. }

• W2998264310 abstract "Abstract Background The aim of this study was to improve the predictive power of patient‐derived xenografts (PDXs, also known as mouse avatars) to more accurately reflect outcomes of clofarabine‐based treatment in pediatric acute lymphoblastic leukemia (ALL) patients. Procedure Pharmacokinetic (PK) studies were conducted using clofarabine at 3.5 to 15 mg/kg in mice. PDXs were established from relapsed/refractory ALL patients who exhibited good or poor responses to clofarabine. PDX engraftment and response to clofarabine (either as a single agent or in combinations) were assessed based on stringent objective response measures modeled after the clinical setting. Results In naïve immune‐deficient NSG mice, we determined that a clofarabine dose of 3.5 mg/kg resulted in systemic exposures equivalent to those achieved in pediatric ALL patients treated with clofarabine‐based regimens. This dose was markedly lower than the doses of clofarabine used in previously reported preclinical studies (typically 30‐60 mg/kg) and, when scheduled consistent with the clinical regimen (daily × 5), resulted in 34‐fold lower clofarabine exposures. Using a well‐tolerated clofarabine/etoposide/cyclophosphamide combination regimen, we then found that the responses of PDXs better reflected the clinical responses of the patients from whom the PDXs were derived. Conclusions This study has identified an in vivo clofarabine treatment regimen that reflects the clinical responses of relapsed/refractory pediatric ALL patients. This regimen could be used prospectively to identify patients who might benefit from clofarabine‐based treatment. Our findings are an important step toward individualizing prospective patient selection for the use of clofarabine in relapsed/refractory pediatric ALL patients and highlight the need for detailed PK evaluation in murine PDX models." @default.
• W2998264310 created "2020-01-10" @default.
• W2998264310 creator A5013139347 @default.
• W2998264310 creator A5020523683 @default.
• W2998264310 creator A5022402043 @default.
• W2998264310 creator A5026619804 @default.
• W2998264310 creator A5029868443 @default.
• W2998264310 creator A5043170079 @default.
• W2998264310 creator A5048901110 @default.
• W2998264310 creator A5056614468 @default.
• W2998264310 creator A5063358141 @default.
• W2998264310 creator A5064388673 @default.
• W2998264310 creator A5067500670 @default.
• W2998264310 creator A5072009574 @default.
• W2998264310 creator A5076557705 @default.
• W2998264310 creator A5078090612 @default.
• W2998264310 creator A5078917865 @default.
• W2998264310 date "2019-12-25" @default.
• W2998264310 modified "2023-10-16" @default.
• W2998264310 title "Optimization of a clofarabine‐based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia" @default.
• W2998264310 cites W1571073982 @default.
• W2998264310 cites W1963779075 @default.
• W2998264310 cites W1970029267 @default.
• W2998264310 cites W1977179006 @default.
• W2998264310 cites W1977862111 @default.
• W2998264310 cites W1986453044 @default.
• W2998264310 cites W1988791872 @default.
• W2998264310 cites W2024950851 @default.
• W2998264310 cites W2038823857 @default.
• W2998264310 cites W2040161091 @default.
• W2998264310 cites W2045977586 @default.
• W2998264310 cites W2049717399 @default.
• W2998264310 cites W2054188819 @default.
• W2998264310 cites W2060421679 @default.
• W2998264310 cites W2070962119 @default.
• W2998264310 cites W2082577618 @default.
• W2998264310 cites W2082870362 @default.
• W2998264310 cites W2088641535 @default.
• W2998264310 cites W2093944145 @default.
• W2998264310 cites W2099242195 @default.
• W2998264310 cites W2101272773 @default.
• W2998264310 cites W2102776788 @default.
• W2998264310 cites W2111008003 @default.
• W2998264310 cites W2116171965 @default.
• W2998264310 cites W2119240494 @default.
• W2998264310 cites W2126358767 @default.
• W2998264310 cites W2130281082 @default.
• W2998264310 cites W2134118606 @default.
• W2998264310 cites W2136346901 @default.
• W2998264310 cites W2141962126 @default.
• W2998264310 cites W2161759378 @default.
• W2998264310 cites W2277664954 @default.
• W2998264310 cites W2344579102 @default.
• W2998264310 cites W2401089748 @default.
• W2998264310 cites W2472104278 @default.
• W2998264310 cites W2581891628 @default.
• W2998264310 cites W2600231501 @default.
• W2998264310 cites W2606966646 @default.
• W2998264310 cites W2751733606 @default.
• W2998264310 doi "https://doi.org/10.1002/pbc.28133" @default.
• W2998264310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31876116" @default.
• W2998264310 hasPublicationYear "2019" @default.
• W2998264310 type Work @default.
• W2998264310 sameAs 2998264310 @default.
• W2998264310 citedByCount "2" @default.
• W2998264310 countsByYear W29982643102021 @default.
• W2998264310 countsByYear W29982643102023 @default.
• W2998264310 crossrefType "journal-article" @default.
• W2998264310 hasAuthorship W2998264310A5013139347 @default.
• W2998264310 hasAuthorship W2998264310A5020523683 @default.
• W2998264310 hasAuthorship W2998264310A5022402043 @default.
• W2998264310 hasAuthorship W2998264310A5026619804 @default.
• W2998264310 hasAuthorship W2998264310A5029868443 @default.
• W2998264310 hasAuthorship W2998264310A5043170079 @default.
• W2998264310 hasAuthorship W2998264310A5048901110 @default.
• W2998264310 hasAuthorship W2998264310A5056614468 @default.
• W2998264310 hasAuthorship W2998264310A5063358141 @default.
• W2998264310 hasAuthorship W2998264310A5064388673 @default.
• W2998264310 hasAuthorship W2998264310A5067500670 @default.
• W2998264310 hasAuthorship W2998264310A5072009574 @default.
• W2998264310 hasAuthorship W2998264310A5076557705 @default.
• W2998264310 hasAuthorship W2998264310A5078090612 @default.
• W2998264310 hasAuthorship W2998264310A5078917865 @default.
• W2998264310 hasConcept C121332964 @default.
• W2998264310 hasConcept C126322002 @default.
• W2998264310 hasConcept C142424586 @default.
• W2998264310 hasConcept C143998085 @default.
• W2998264310 hasConcept C2777198975 @default.
• W2998264310 hasConcept C2778041864 @default.
• W2998264310 hasConcept C2778461978 @default.
• W2998264310 hasConcept C2781413609 @default.
• W2998264310 hasConcept C535046627 @default.
• W2998264310 hasConcept C71924100 @default.
• W2998264310 hasConcept C87355193 @default.
• W2998264310 hasConceptScore W2998264310C121332964 @default.
• W2998264310 hasConceptScore W2998264310C126322002 @default.
• W2998264310 hasConceptScore W2998264310C142424586 @default.
• W2998264310 hasConceptScore W2998264310C143998085 @default.
• W2998264310 hasConceptScore W2998264310C2777198975 @default.
• W2998264310 hasConceptScore W2998264310C2778041864 @default.

• next