Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998323822> ?p ?o ?g. }
- W2998323822 abstract "Abstract The classical drug development pipeline necessitates studies using animal models of human disease to gauge future efficacy in humans, however, there is a comparatively low conversion rate from success in animals to in humans. Non-alcoholic fatty liver disease (NAFLD) is a complex chronic disease without any licensed therapies and hence a major field of animal research. We performed a meta-analysis of 414 interventional rodent studies (6,575 animals) in NAFLD to assess the mean difference in hepatic triglyceride content. 20 of 21 studied drug classes had similar efficacy with a mean difference of −30% hepatic triglyceride. However, when publication bias was accounted for, this reduced to −16% difference. Study characteristics were only able to account for a minority of variability on meta-regression, and we replicated previous findings of high risk of bias across 82% of cohorts. These findings build on previous work in preclinical neuroscience and help to explain the challenge of reproducibility and translation within the field of metabolism." @default.
- W2998323822 created "2020-01-10" @default.
- W2998323822 creator A5019397735 @default.
- W2998323822 creator A5021744286 @default.
- W2998323822 creator A5024406598 @default.
- W2998323822 creator A5028551568 @default.
- W2998323822 creator A5031327536 @default.
- W2998323822 creator A5033407265 @default.
- W2998323822 creator A5034587790 @default.
- W2998323822 creator A5036164677 @default.
- W2998323822 creator A5039516363 @default.
- W2998323822 creator A5043756310 @default.
- W2998323822 creator A5050352393 @default.
- W2998323822 creator A5062506190 @default.
- W2998323822 creator A5069313135 @default.
- W2998323822 creator A5078382333 @default.
- W2998323822 creator A5080061160 @default.
- W2998323822 creator A5081242943 @default.
- W2998323822 date "2019-12-31" @default.
- W2998323822 modified "2023-10-16" @default.
- W2998323822 title "What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression" @default.
- W2998323822 cites W1523155649 @default.
- W2998323822 cites W1583321927 @default.
- W2998323822 cites W1950977525 @default.
- W2998323822 cites W1971092719 @default.
- W2998323822 cites W2000053231 @default.
- W2998323822 cites W2023380764 @default.
- W2998323822 cites W2033585778 @default.
- W2998323822 cites W2050034605 @default.
- W2998323822 cites W2058148588 @default.
- W2998323822 cites W2062812115 @default.
- W2998323822 cites W2065655717 @default.
- W2998323822 cites W2084889414 @default.
- W2998323822 cites W2085452046 @default.
- W2998323822 cites W2099067203 @default.
- W2998323822 cites W2100068213 @default.
- W2998323822 cites W2109963121 @default.
- W2998323822 cites W2116952900 @default.
- W2998323822 cites W2120244696 @default.
- W2998323822 cites W2136462620 @default.
- W2998323822 cites W2137516955 @default.
- W2998323822 cites W2141759041 @default.
- W2998323822 cites W2152652033 @default.
- W2998323822 cites W2156665896 @default.
- W2998323822 cites W2156801000 @default.
- W2998323822 cites W2162382402 @default.
- W2998323822 cites W2164074199 @default.
- W2998323822 cites W2164759539 @default.
- W2998323822 cites W2215535790 @default.
- W2998323822 cites W2406493898 @default.
- W2998323822 cites W2422375524 @default.
- W2998323822 cites W2513840036 @default.
- W2998323822 cites W2522782769 @default.
- W2998323822 cites W2560438049 @default.
- W2998323822 cites W2600119935 @default.
- W2998323822 cites W2734724639 @default.
- W2998323822 cites W2759997926 @default.
- W2998323822 cites W2761773860 @default.
- W2998323822 cites W2769826158 @default.
- W2998323822 cites W2805710986 @default.
- W2998323822 cites W2809030969 @default.
- W2998323822 cites W2810423511 @default.
- W2998323822 cites W2884823863 @default.
- W2998323822 cites W2887350709 @default.
- W2998323822 cites W2899389750 @default.
- W2998323822 cites W2922156643 @default.
- W2998323822 cites W2940657120 @default.
- W2998323822 cites W2955603751 @default.
- W2998323822 cites W2955835094 @default.
- W2998323822 cites W784232644 @default.
- W2998323822 doi "https://doi.org/10.1101/2019.12.31.887919" @default.
- W2998323822 hasPublicationYear "2019" @default.
- W2998323822 type Work @default.
- W2998323822 sameAs 2998323822 @default.
- W2998323822 citedByCount "0" @default.
- W2998323822 crossrefType "posted-content" @default.
- W2998323822 hasAuthorship W2998323822A5019397735 @default.
- W2998323822 hasAuthorship W2998323822A5021744286 @default.
- W2998323822 hasAuthorship W2998323822A5024406598 @default.
- W2998323822 hasAuthorship W2998323822A5028551568 @default.
- W2998323822 hasAuthorship W2998323822A5031327536 @default.
- W2998323822 hasAuthorship W2998323822A5033407265 @default.
- W2998323822 hasAuthorship W2998323822A5034587790 @default.
- W2998323822 hasAuthorship W2998323822A5036164677 @default.
- W2998323822 hasAuthorship W2998323822A5039516363 @default.
- W2998323822 hasAuthorship W2998323822A5043756310 @default.
- W2998323822 hasAuthorship W2998323822A5050352393 @default.
- W2998323822 hasAuthorship W2998323822A5062506190 @default.
- W2998323822 hasAuthorship W2998323822A5069313135 @default.
- W2998323822 hasAuthorship W2998323822A5078382333 @default.
- W2998323822 hasAuthorship W2998323822A5080061160 @default.
- W2998323822 hasAuthorship W2998323822A5081242943 @default.
- W2998323822 hasBestOaLocation W29983238221 @default.
- W2998323822 hasConcept C11171543 @default.
- W2998323822 hasConcept C124936440 @default.
- W2998323822 hasConcept C126322002 @default.
- W2998323822 hasConcept C15744967 @default.
- W2998323822 hasConcept C172268261 @default.
- W2998323822 hasConcept C2776175330 @default.
- W2998323822 hasConcept C2778163477 @default.