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• W2998329260 endingPage "100205" @default.
• W2998329260 startingPage "100205" @default.
• W2998329260 abstract "Silver nanoparticles (AgNPs) are used in food packaging materials, dental care products and other consumer goods and can result in oral exposure. To determine whether AgNP coatings modulate transcriptional responses to AgNP exposure, we exposed mice orally to 20 nm citrate (cit)-coated AgNPs (cit-AgNPs) or polyvinylpyrrolidone (PVP)-coated AgNPs (PVP-AgNPs) at a 4 mg/kg dose for 7 consecutive days and analyzed changes in the expression of protein-coding genes and long noncoding RNAs (lncRNAs), a new class of regulatory RNAs, in the liver. We identified unique and common expression signatures of protein-coding and lncRNA genes, altered biological processes and signaling pathways, and coding-non-coding gene interactions for cit-AgNPs and PVP-AgNPs. Commonly regulated genes comprised only about 10 and 20 percent of all differentially expressed genes in PVP-AgNP and cit-AgNP exposed mice, respectively. Commonly regulated biological processes included glutathione metabolic process and cellular oxidant detoxification. Commonly regulated pathways included Keap-Nrf2, PPAR, MAPK and IL-6 signaling pathways. The coding-non-coding gene co-expression analysis revealed that protein-coding genes were co-expressed with a variable number of lncRNAs ranging from one to twenty three and may share functional roles with the protein-coding genes. PVP-AgNP exposure induced a more robust transcriptional response than cit-AgNP exposure characterized by more than two-fold higher number of differentially expressed both protein- coding and lncRNA genes. Our data demonstrate that the surface coating strongly modulates the spectrum and the number of differentially expressed genes after oral AgNP exposure. On the other hand, our data suggest that AgNP exposure can alter drug and chemical sensitivity, metabolic homeostasis and cancer risk irrespective of the coating type, warranting further investigations." @default.
• W2998329260 created "2020-01-10" @default.
• W2998329260 creator A5042838200 @default.
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• W2998329260 date "2020-01-01" @default.
• W2998329260 modified "2023-09-29" @default.
• W2998329260 title "Surface coatings alter transcriptional responses to silver nanoparticles following oral exposure" @default.
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• W2998329260 cites W1965724633 @default.
• W2998329260 cites W1968509967 @default.
• W2998329260 cites W1969691695 @default.
• W2998329260 cites W1974709573 @default.
• W2998329260 cites W1982494232 @default.
• W2998329260 cites W1985003639 @default.
• W2998329260 cites W1988069937 @default.
• W2998329260 cites W2000655486 @default.
• W2998329260 cites W2001644369 @default.
• W2998329260 cites W2025569306 @default.
• W2998329260 cites W2029822640 @default.
• W2998329260 cites W2035538736 @default.
• W2998329260 cites W2036098906 @default.
• W2998329260 cites W2038442946 @default.
• W2998329260 cites W2040210681 @default.
• W2998329260 cites W2040519690 @default.
• W2998329260 cites W2046750894 @default.
• W2998329260 cites W2046824265 @default.
• W2998329260 cites W2050553698 @default.
• W2998329260 cites W2051702988 @default.
• W2998329260 cites W2057036895 @default.
• W2998329260 cites W2062005522 @default.
• W2998329260 cites W2068859969 @default.
• W2998329260 cites W2071636590 @default.
• W2998329260 cites W2073703119 @default.
• W2998329260 cites W2073930201 @default.
• W2998329260 cites W2076071077 @default.
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• W2998329260 cites W2122660076 @default.
• W2998329260 cites W2132714700 @default.
• W2998329260 cites W2133465414 @default.
• W2998329260 cites W2133533473 @default.
• W2998329260 cites W2138071609 @default.
• W2998329260 cites W2146385374 @default.
• W2998329260 cites W2151048962 @default.
• W2998329260 cites W2153103173 @default.
• W2998329260 cites W2156615630 @default.
• W2998329260 cites W2157972644 @default.
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• W2998329260 cites W2312108633 @default.
• W2998329260 cites W2315539895 @default.
• W2998329260 cites W2317184793 @default.
• W2998329260 cites W2336991720 @default.
• W2998329260 cites W2500440340 @default.
• W2998329260 cites W2508865277 @default.
• W2998329260 cites W2580466457 @default.
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• W2998329260 doi "https://doi.org/10.1016/j.impact.2019.100205" @default.
• W2998329260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7453744" @default.
• W2998329260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32864508" @default.
• W2998329260 hasPublicationYear "2020" @default.
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