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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998343230> ?p ?o ?g. }

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• W2998343230 abstract "The effects of a single-amino-acid culture strategy on secondary metabolite production in the marine-derived fungus Trichoderma erinaceum F1-1 were investigated by culturing the fungus in GPY medium supplemented or not supplemented with l-phenylalanine. A suite of secondary metabolites, including seven terpenoids (1–7) and one polyketide (8), among which are four new compounds, harziandione A (1), cyclonerodiols A and B (3, 4), and trichodermaerin A (6), were isolated from the GPY medium without l-phenylanine, whereas 18 aromatic compounds (9–26), including six new compounds, trichoderolides A–F (9, 10, and 14–17), were isolated from the culture grown in the GPY medium with l-phenylalanine. The structures of the new compounds were determined by high-resolution mass spectrometry, NMR spectroscopic analysis, optical rotation calculations, chemical methods, and X-ray crystallography. Compounds 10, 12, 13, and 26 exhibited cytotoxic activities against MDA-MB-435 human melanocyte cancer cells. Compound 26 was cytotoxic to A549 adenocarcinomic human alveolar basal epithelial cells." @default.
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• W2998343230 date "2019-12-30" @default.
• W2998343230 modified "2023-10-02" @default.
• W2998343230 title "<scp>l</scp>-Phenylalanine Alters the Privileged Secondary Metabolite Production in the Marine-Derived Fungus <i>Trichoderma erinaceum</i> F1-1" @default.
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• W2998343230 doi "https://doi.org/10.1021/acs.jnatprod.9b00710" @default.
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