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• W2998366920 abstract "Objective Initial treatment options for Graves’ disease include antithyroid drugs, radioactive iodine (RAI), and surgery. Because of similar effects of three modalities, initial treatment preferences differ by country to country. In Korea, iodine-replete area, RAI was used as a second-line option. For these reasons, the RAI success rate in Korea might differ from other countries. Methods A total of 247 patients were enrolled. The primary outcome was cumulative success rate in the first year, and the secondary outcome was factors that affected the success. Delayed response, which included patients who attained successful RAI during the follow-up, after the first year without further RAI, and factors that affected the delayed response were reviewed. Results The cumulative success rate in the first year was 62.8%. Higher RAI activity [odds ratio (OR) 2.56, P = 0.02], longer disease duration (OR 0.43, P = 0.01), larger goiter (OR 0.31, P = 0.01), and higher post-RAI fT4 (fT4 between upper normal limit (UNL) to 1.5 × UNL; OR 0.24; P < 0.01, 1.5 × UNL<; OR 0.08; P < 0.01) were associated with RAI success. Twenty-seven patients showed delayed response, and goiter size ( P < 0.05), pre-RAI TSH receptor Ab (TRAb) level ( P < 0.01) and post-RAI fT4 ( P < 0.01) were associated. Conclusion The success rate of the first RAI in Korea was lower than that in other countries. Delayed response was observed in patients with smaller goiter, low pre-RAI TRAb, and low post-RAI fT4. In these patients, clinical follow-up with monitoring could be an option, and decision of optimal timing of first RAI is crucial." @default.
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• W2998366920 date "2020-03-01" @default.
• W2998366920 modified "2023-09-26" @default.
• W2998366920 title "The success rate of radioactive iodine therapy for Graves’ disease in iodine-replete area and affecting factors" @default.
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• W2998366920 doi "https://doi.org/10.1097/mnm.0000000000001138" @default.
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