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- W2998401471 abstract "To establish the role of natural AAT class IgG to nerve tissue proteins (S-100, GFAP, NF-200, and MBP) in the pathogenesis of damage to the nervous system in HIV. The level of autoantibodies to neurotropic proteins was determined in the serum of 99 patients with HIV infection. In the course of the study, four groups of patients were identified: HC lesions, conditionally not related to HIV, but caused by stress, toxic-allergic effects, the presence of somatic pathology, and other factors (48 patients, 48.5%; group 1); with primary lesion of the nervous system of HIV without significant immunodeficiency (primary neuro-AIDS - 9.1% (9 patients); group 2 - with secondary damage to the nervous system and severe immunodeficiency (secondary neuro-AIDS - 22.2% (22 patients); In clinically healthy individuals (control group), the determined parameters were distributed as follows: AAT S100 - 77.5 ± 7.6 cu, AAT GFAP - 57.9 ± 5.7 cu, AAT NF- 200 - 72.9 ± 7.1 USD, AAT MBP - 58.8 ± 5.5 USD The highest among the studied AAT in all groups was the level of AAT to S100, while in patients with HC lesions against HIV, this figure exceeded the standard values by an average of 1.9 times (P <0.01), and in patients without HC damage - 1.6 times (P <0.05). Thus, the clinical and immunological analysis revealed a clear pattern in the content of antibodies to neurotropic proteins depending on the presence of NS damage in HIV." @default.
- W2998401471 created "2020-01-10" @default.
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- W2998401471 date "2019-10-01" @default.
- W2998401471 modified "2023-09-24" @default.
- W2998401471 title "The role of natural autoantibodies to the nervous system proteins in neuro-aids in uzbekistan" @default.
- W2998401471 doi "https://doi.org/10.1016/j.jns.2019.10.1048" @default.
- W2998401471 hasPublicationYear "2019" @default.
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