FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998487988> ?p ?o ?g. }

• W2998487988 endingPage "103588" @default.
• W2998487988 startingPage "103588" @default.
• W2998487988 abstract "Haemophilus parasuis infection causes typical acute systemic inflammation in pigs, is characterized by fibrinous polyserositis inflammation, and results in great economic losses to the swine industry worldwide. However, the molecular details of how the host modulates the acute inflammatory response induced by H. parasuis are largely unknown. In previous studies, we found that H. parasuis high-virulence strain SH0165 infection induced the activation of both Wnt/β-catenin and NF-κB signaling in PK-15 and NPTr cells. In this study, we found that the activation of NF-κB, a central hub in inflammatory signaling, was impeded by the Wnt/β-catenin pathway during H. parasuis infection. In contrast, blocking NF-κB activity had no effect on the Wnt/β-catenin pathway during H. parasuis infection. Furthermore, we found that the inhibitory effect of β-catenin on NF-κB activity was mediated by its target gene, pig cyclooxygenase-2 (COX-2). Therefore, we demonstrated that H. parasuis infection activates the canonical Wnt/β-catenin signaling pathway, which leads to decreased NF-κB activity, reducing the acute inflammatory response in pigs. Additionally, the data provide a possible perspective for understanding the anti-inflammatory role of Wnt/β-catenin in pigs during bacterial infection." @default.
• W2998487988 created "2020-01-10" @default.
• W2998487988 creator A5000182682 @default.
• W2998487988 creator A5021897788 @default.
• W2998487988 creator A5025048843 @default.
• W2998487988 creator A5040189982 @default.
• W2998487988 creator A5040731634 @default.
• W2998487988 creator A5045973583 @default.
• W2998487988 creator A5054220107 @default.
• W2998487988 creator A5076509097 @default.
• W2998487988 creator A5081055919 @default.
• W2998487988 date "2020-04-01" @default.
• W2998487988 modified "2023-10-14" @default.
• W2998487988 title "COX-2 mediated crosstalk between Wnt/β-catenin and the NF-κB signaling pathway during inflammatory responses induced by Haemophilus parasuis in PK-15 and NPTr cells" @default.
• W2998487988 cites W1539392991 @default.
• W2998487988 cites W1542188496 @default.
• W2998487988 cites W1825590475 @default.
• W2998487988 cites W1866696283 @default.
• W2998487988 cites W1939041072 @default.
• W2998487988 cites W1941492958 @default.
• W2998487988 cites W1958512987 @default.
• W2998487988 cites W1977366167 @default.
• W2998487988 cites W1979993283 @default.
• W2998487988 cites W1980767418 @default.
• W2998487988 cites W1981956953 @default.
• W2998487988 cites W1982336014 @default.
• W2998487988 cites W1983710466 @default.
• W2998487988 cites W1998392042 @default.
• W2998487988 cites W1999014255 @default.
• W2998487988 cites W2000476027 @default.
• W2998487988 cites W2004827058 @default.
• W2998487988 cites W2007187686 @default.
• W2998487988 cites W2012919091 @default.
• W2998487988 cites W2020018765 @default.
• W2998487988 cites W2026219104 @default.
• W2998487988 cites W2028183785 @default.
• W2998487988 cites W2038249157 @default.
• W2998487988 cites W2039096622 @default.
• W2998487988 cites W2042092530 @default.
• W2998487988 cites W2046167310 @default.
• W2998487988 cites W2061965920 @default.
• W2998487988 cites W2083905520 @default.
• W2998487988 cites W2086513193 @default.
• W2998487988 cites W2088905899 @default.
• W2998487988 cites W2111394514 @default.
• W2998487988 cites W2119284420 @default.
• W2998487988 cites W2125296092 @default.
• W2998487988 cites W2141459104 @default.
• W2998487988 cites W2148037755 @default.
• W2998487988 cites W2164702681 @default.
• W2998487988 cites W2171057897 @default.
• W2998487988 cites W2229330024 @default.
• W2998487988 cites W2522422641 @default.
• W2998487988 cites W2567464583 @default.
• W2998487988 cites W2602642359 @default.
• W2998487988 cites W2735527928 @default.
• W2998487988 cites W2888385645 @default.
• W2998487988 cites W995332402 @default.
• W2998487988 cites W2766900271 @default.
• W2998487988 doi "https://doi.org/10.1016/j.dci.2019.103588" @default.
• W2998487988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31887319" @default.
• W2998487988 hasPublicationYear "2020" @default.
• W2998487988 type Work @default.
• W2998487988 sameAs 2998487988 @default.
• W2998487988 citedByCount "9" @default.
• W2998487988 countsByYear W29984879882021 @default.
• W2998487988 countsByYear W29984879882022 @default.
• W2998487988 countsByYear W29984879882023 @default.
• W2998487988 crossrefType "journal-article" @default.
• W2998487988 hasAuthorship W2998487988A5000182682 @default.
• W2998487988 hasAuthorship W2998487988A5021897788 @default.
• W2998487988 hasAuthorship W2998487988A5025048843 @default.
• W2998487988 hasAuthorship W2998487988A5040189982 @default.
• W2998487988 hasAuthorship W2998487988A5040731634 @default.
• W2998487988 hasAuthorship W2998487988A5045973583 @default.
• W2998487988 hasAuthorship W2998487988A5054220107 @default.
• W2998487988 hasAuthorship W2998487988A5076509097 @default.
• W2998487988 hasAuthorship W2998487988A5081055919 @default.
• W2998487988 hasConcept C120665830 @default.
• W2998487988 hasConcept C121332964 @default.
• W2998487988 hasConcept C137620995 @default.
• W2998487988 hasConcept C169822122 @default.
• W2998487988 hasConcept C203014093 @default.
• W2998487988 hasConcept C2776402342 @default.
• W2998487988 hasConcept C2776914184 @default.
• W2998487988 hasConcept C2777730290 @default.
• W2998487988 hasConcept C2779324961 @default.
• W2998487988 hasConcept C30145163 @default.
• W2998487988 hasConcept C502942594 @default.
• W2998487988 hasConcept C523546767 @default.
• W2998487988 hasConcept C54355233 @default.
• W2998487988 hasConcept C62478195 @default.
• W2998487988 hasConcept C86803240 @default.
• W2998487988 hasConcept C89423630 @default.
• W2998487988 hasConcept C95444343 @default.
• W2998487988 hasConceptScore W2998487988C120665830 @default.
• W2998487988 hasConceptScore W2998487988C121332964 @default.
• W2998487988 hasConceptScore W2998487988C137620995 @default.

• next