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- W2998492084 abstract "A 70-year-old woman with symmetric parkinsonism and vertical gaze paresis had an elevated serum manganese level at 60.1 ng/mL (reference value, 4.7–18.3 ng/mL) because of daily over-the-counter supplement intake (over 500% of recommended dietary allowance). Brain MRI revealed T1 hyperintensities in the bilateral globus pallidi and subthalamic nuclei (figure). Serum level normalized with partial clinical improvement after stopping the supplement intake, but the imaging remained unchanged a year later. Liver and kidney failure, occupational exposure, ephedrine usage, parenteral nutrition, and manganese transporter defects may cause similar imaging findings attributable to hypermanganesemia,1,2 but these causes were ruled out." @default.
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- W2998492084 date "2020-01-03" @default.
- W2998492084 modified "2023-09-29" @default.
- W2998492084 title "Manganese Supplementation as a Cause of Parkinsonism and T1-Hyperintensities on Basal Ganglia" @default.
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- W2998492084 doi "https://doi.org/10.1212/cpj.0000000000000804" @default.
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