FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998492703> ?p ?o ?g. }

• W2998492703 endingPage "84" @default.
• W2998492703 startingPage "77" @default.
• W2998492703 abstract "The penile bulb (PB) dose may be critical in development of post prostate radiotherapy erectile dysfunction (ED). This study aimed to generate PB dose constraints based on dose-volume histograms (DVHs) in patients treated with prostate radiotherapy, and to identify clinical and dosimetric parameters that predict the risk of ED post prostate radiotherapy.Penile bulb DVHs were generated for 276 patients treated within the randomised IGRT substudy of the multicentre randomised trial, CHHiP. Incidence of ED in relation to dose and randomised IGRT groups were evaluated using Wilcoxon rank sum, Chi-squared test and atlases of complication incidence. Youden index was used to find dose-volume constraints that discriminated for ED. Multivariate analysis (MVA) of effect of dosimetry, clinical and patient-related variables was performed.Reduced treatment margins using IGRT (IGRT-R) produced significantly reduced mean PB dose compared with standard margins (IGRT-S) (median: 25 Gy (IGRT-S) versus 11 Gy (IGRT-R); p < 0.0001). Significant difference in both mean (median: 23 Gy (ED) vs. 18 Gy (no ED); p = 0.011) and maximum (median: 59 Gy (ED) vs. 52 Gy (no ED); p = 0.018) PB doses between those with and without clinician reported ED were identified. Mean PB dose cut-point for ED was derived at around 20 Gy. On MVA, PB mean dose and age predicted for impotence.PB dose appears predictive of post-radiotherapy ED with calculated threshold mean dose of around 20 Gy, substantially lower than published recommendations. IGRT-R enables favourable PB dosimetry and can be recommended provided prostate coverage is not compromised." @default.
• W2998492703 created "2020-01-10" @default.
• W2998492703 creator A5003388016 @default.
• W2998492703 creator A5007511184 @default.
• W2998492703 creator A5015145551 @default.
• W2998492703 creator A5020643912 @default.
• W2998492703 creator A5025921361 @default.
• W2998492703 creator A5026115891 @default.
• W2998492703 creator A5031724034 @default.
• W2998492703 creator A5036855884 @default.
• W2998492703 creator A5041969793 @default.
• W2998492703 creator A5045062892 @default.
• W2998492703 creator A5056063646 @default.
• W2998492703 creator A5059792318 @default.
• W2998492703 creator A5061315350 @default.
• W2998492703 creator A5062480470 @default.
• W2998492703 creator A5070672807 @default.
• W2998492703 creator A5079070729 @default.
• W2998492703 creator A5080362183 @default.
• W2998492703 creator A5082017426 @default.
• W2998492703 creator A5085092777 @default.
• W2998492703 date "2020-03-01" @default.
• W2998492703 modified "2023-10-16" @default.
• W2998492703 title "Evaluation of erectile potency and radiation dose to the penile bulb using image guided radiotherapy in the CHHiP trial" @default.
• W2998492703 cites W1484985634 @default.
• W2998492703 cites W1552327084 @default.
• W2998492703 cites W1965657915 @default.
• W2998492703 cites W1966072080 @default.
• W2998492703 cites W1992823803 @default.
• W2998492703 cites W2003218091 @default.
• W2998492703 cites W2005940465 @default.
• W2998492703 cites W2008118429 @default.
• W2998492703 cites W2012285222 @default.
• W2998492703 cites W2015071129 @default.
• W2998492703 cites W2025002838 @default.
• W2998492703 cites W2031687235 @default.
• W2998492703 cites W2035429331 @default.
• W2998492703 cites W2065493387 @default.
• W2998492703 cites W2068796302 @default.
• W2998492703 cites W2081294165 @default.
• W2998492703 cites W2087887727 @default.
• W2998492703 cites W2103351853 @default.
• W2998492703 cites W2106291938 @default.
• W2998492703 cites W2108006937 @default.
• W2998492703 cites W2108569878 @default.
• W2998492703 cites W2111180711 @default.
• W2998492703 cites W2115483503 @default.
• W2998492703 cites W2140468511 @default.
• W2998492703 cites W2152575748 @default.
• W2998492703 cites W2165422473 @default.
• W2998492703 cites W2297358297 @default.
• W2998492703 cites W2337386322 @default.
• W2998492703 cites W2342114119 @default.
• W2998492703 cites W2465092116 @default.
• W2998492703 cites W2523396458 @default.
• W2998492703 doi "https://doi.org/10.1016/j.ctro.2019.12.006" @default.
• W2998492703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7013161" @default.
• W2998492703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32072028" @default.
• W2998492703 hasPublicationYear "2020" @default.
• W2998492703 type Work @default.
• W2998492703 sameAs 2998492703 @default.
• W2998492703 citedByCount "16" @default.
• W2998492703 countsByYear W29984927032020 @default.
• W2998492703 countsByYear W29984927032021 @default.
• W2998492703 countsByYear W29984927032022 @default.
• W2998492703 countsByYear W29984927032023 @default.
• W2998492703 crossrefType "journal-article" @default.
• W2998492703 hasAuthorship W2998492703A5003388016 @default.
• W2998492703 hasAuthorship W2998492703A5007511184 @default.
• W2998492703 hasAuthorship W2998492703A5015145551 @default.
• W2998492703 hasAuthorship W2998492703A5020643912 @default.
• W2998492703 hasAuthorship W2998492703A5025921361 @default.
• W2998492703 hasAuthorship W2998492703A5026115891 @default.
• W2998492703 hasAuthorship W2998492703A5031724034 @default.
• W2998492703 hasAuthorship W2998492703A5036855884 @default.
• W2998492703 hasAuthorship W2998492703A5041969793 @default.
• W2998492703 hasAuthorship W2998492703A5045062892 @default.
• W2998492703 hasAuthorship W2998492703A5056063646 @default.
• W2998492703 hasAuthorship W2998492703A5059792318 @default.
• W2998492703 hasAuthorship W2998492703A5061315350 @default.
• W2998492703 hasAuthorship W2998492703A5062480470 @default.
• W2998492703 hasAuthorship W2998492703A5070672807 @default.
• W2998492703 hasAuthorship W2998492703A5079070729 @default.
• W2998492703 hasAuthorship W2998492703A5080362183 @default.
• W2998492703 hasAuthorship W2998492703A5082017426 @default.
• W2998492703 hasAuthorship W2998492703A5085092777 @default.
• W2998492703 hasBestOaLocation W29984927031 @default.
• W2998492703 hasConcept C121608353 @default.
• W2998492703 hasConcept C126322002 @default.
• W2998492703 hasConcept C126838900 @default.
• W2998492703 hasConcept C126894567 @default.
• W2998492703 hasConcept C141071460 @default.
• W2998492703 hasConcept C168563851 @default.
• W2998492703 hasConcept C2776235491 @default.
• W2998492703 hasConcept C2779929075 @default.
• W2998492703 hasConcept C2989005 @default.
• W2998492703 hasConcept C509974204 @default.
• W2998492703 hasConcept C71924100 @default.

• next