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- W2998509323 abstract "Tanzania is one of the countries confronting a multidrug-resistant tuberculosis (MDR-TB) epidemic.Research studies on drug susceptibility testing (DST) for second-line TB drugs given to Tanzanian MDR-TB patients has demonstrated mycobacterial resistance to important MDR-TB drugs, such as ethionamide, ofloxacin, amikacin, kanamycin, and pyrazinamide. Likewise, pharmacokinetic studies have shown a high frequency of patients with circulating serum drug levels below the expected ranges, especially for levofloxacin and kanamycin - key drugs in MDR-TB treatment that also affect ex-vivo plasma drug activity.We suggest using molecular diagnostic assays, such as the GenoType MTBDRplus test, and inhA and/or katG genotypic results to optimize MDR-TB treatment. Quantitative drug susceptibility can guide the selection of options for second-line anti-TB drugs. The TB drug assay, an alternative biomarker for therapeutic drug monitoring, can identify patients who have extensively drug-resistant TB or are exposed to suboptimal serum drug levels of, specifically, levofloxacin and kanamycin." @default.
- W2998509323 created "2020-01-10" @default.
- W2998509323 creator A5069498331 @default.
- W2998509323 date "2018-04-01" @default.
- W2998509323 modified "2023-09-22" @default.
- W2998509323 title "Diagnostic Opportunities for Optimizing Management of Multidrug-Resistant Tuberculosis (MDR-TB) in Tanzania" @default.
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- W2998509323 doi "https://doi.org/10.24248/eahrj.v2i1.563" @default.
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