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- W2998513404 abstract "Abstract BACKGROUND An imbalanced fat or excess energy intake always results in obesity and increased serum/liver lipids, thus leading to metabolic syndromes. Given the bioactive components in black vinegar (BV), such as branched amino acids, phenolic profile, and mineral contents, we investigated the antiobesity effects of BV‐based supplements in rats fed a high‐fat diet (HFD). RESULTS HFD (30% fat, w/w) feeding increased ( P < 0.05) body weight, weight gains, weights of livers and mesenteric, epididymal, and perirenal adipose tissues, and serum/liver triglyceride levels relative to those of rats fed a normal diet (4% fat, w/w; CON). These increased values were ameliorated ( P < 0.05) by supplementing with BV‐based supplements but were still higher ( P < 0.05) than those of CON rats. The increased areas of perirenal adipocytes in rats fed with an HFD were also decreased ( P < 0.05) by supplementing with BV‐based supplements, which might result from an upregulation ( P < 0.05) of 5′‐adenosine monophosphate‐activated protein kinase (AMPK), carnitine palmitoyltransferase‐1 (CPT1), and uncoupling protein‐2 (UCP2) in the perirenal adipose tissues. A similar effect was observed for AMPK, peroxisome proliferator‐activated receptor alpha, retinoid X receptor alpha, CPT1, and UCP2 gene and protein levels in livers ( P < 0.05). Generally, BV‐based supplements increased the fecal triglyceride, cholesterol, and bile acid levels of rats fed with an HFD, which partially contribute to the lipid‐lowering effects. Furthermore, BV‐based supplements increased ( P < 0.05) hepatic Trolox equivalent antioxidant capacity and lowered ( P < 0.05) serum/liver thiobarbituric acid reactive substances values in HFD‐fed rats. CONCLUSION In a chronic high‐fat dietary habit, the food‐grade BV‐based supplement is a good daily choice to ameliorate obesity and its associated comorbidities. © 2020 Society of Chemical Industry" @default.
- W2998513404 created "2020-01-10" @default.
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- W2998513404 date "2020-02-09" @default.
- W2998513404 modified "2023-10-16" @default.
- W2998513404 title "Modulation effects of black‐vinegar‐based supplement against a high‐fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy‐metabolism effects" @default.
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- W2998513404 doi "https://doi.org/10.1002/jsfa.10246" @default.
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