Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998516385> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- W2998516385 endingPage "5" @default.
- W2998516385 startingPage "1" @default.
- W2998516385 abstract "Sodium polystyrene sulfonate (Kayexalate) or its analog calcium polystyrene sulfonate (Kalimate) has long been used to treat hyperkalemia in patients with chronic kidney disease (CKD). Although the side effect was rare, there were many case reports in the literature. Its etiology remains unclear. Lillemoe et al., on five uremic patients who developed catastrophic colonic necrosis that was temporally associated with the use of Kayexalate in sorbitol, contributed to death in four of their patients. They further provided experimental evidence implicating sorbitol as the agent responsible for colonic necrosis in a rat model. In contrast to the results of aforementioned animal study, Ayoub et al., published another experimental study in rats, they demonstrated that sodium polystyrene sulfonate (SPS), not sorbitol, was the main culprit for colonic necrosis. Recently, we encountered three patients who had hyperkalemia and were on Kalimate in water. They underwent colonic and gastric biopsy because of developing gastrointestinal symptoms. Kalimate crystals were found in all biopsy specimen, admixed with inflammatory exudate, or standing along on the mucosa surface, without provoking inflammatory reaction. We reviewed the photographs in the published case reports, they were similar to ours. Therefore, we felt that those crystals were bystanders, not the culprits. We fell that SPS ion-exchange resins, if given in water, appears to be clinically effective and reasonably safe to treat hyperkalemia in patients with CKD." @default.
- W2998516385 created "2020-01-10" @default.
- W2998516385 creator A5079909582 @default.
- W2998516385 creator A5081638629 @default.
- W2998516385 date "2020-01-01" @default.
- W2998516385 modified "2023-09-25" @default.
- W2998516385 title "Kayexalate or Kalimate crystals: are they the culprits or the bystanders?" @default.
- W2998516385 cites W1869638475 @default.
- W2998516385 cites W1997684146 @default.
- W2998516385 cites W2030933332 @default.
- W2998516385 cites W2032773198 @default.
- W2998516385 cites W2101879409 @default.
- W2998516385 cites W2142892047 @default.
- W2998516385 cites W2312618210 @default.
- W2998516385 cites W2312902017 @default.
- W2998516385 cites W41008109 @default.
- W2998516385 doi "https://doi.org/10.28933/ojgh-2019-12-0205" @default.
- W2998516385 hasPublicationYear "2020" @default.
- W2998516385 type Work @default.
- W2998516385 sameAs 2998516385 @default.
- W2998516385 citedByCount "0" @default.
- W2998516385 crossrefType "journal-article" @default.
- W2998516385 hasAuthorship W2998516385A5079909582 @default.
- W2998516385 hasAuthorship W2998516385A5081638629 @default.
- W2998516385 hasBestOaLocation W29985163851 @default.
- W2998516385 hasConcept C192562407 @default.
- W2998516385 hasConceptScore W2998516385C192562407 @default.
- W2998516385 hasLocation W29985163851 @default.
- W2998516385 hasOpenAccess W2998516385 @default.
- W2998516385 hasPrimaryLocation W29985163851 @default.
- W2998516385 hasRelatedWork W1997684146 @default.
- W2998516385 hasRelatedWork W2047967234 @default.
- W2998516385 hasRelatedWork W2088554911 @default.
- W2998516385 hasRelatedWork W2319622888 @default.
- W2998516385 hasRelatedWork W2421856058 @default.
- W2998516385 hasRelatedWork W2439875401 @default.
- W2998516385 hasRelatedWork W3212622766 @default.
- W2998516385 hasRelatedWork W4241302039 @default.
- W2998516385 hasRelatedWork W4255483855 @default.
- W2998516385 hasRelatedWork W2525756941 @default.
- W2998516385 isParatext "false" @default.
- W2998516385 isRetracted "false" @default.
- W2998516385 magId "2998516385" @default.
- W2998516385 workType "article" @default.