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- W2998532192 abstract "Multiple sclerosis (MS) is the most common acquired neurological disease affecting Young adults. It leads to myelin destruction and formation of lesions in the brain and permeabilization of the blood-brain barrier (BBB).Gadolinium based contrast agents (GBCA), used for diagnosis and monitoring by MRI, might accumulate in tissue, including brain. Using an animal model, application of linear and macrocyclic GBCA was investigated. Analysis was performed by laser ablation inductively coupled plasma (LA-ICP) MS. This method works as a bioimaging tool for sample thin sections and allows to identify regions of accumulated Gd in the samples.In healthy and diseased mice, inflammationmediated changes in the brain were investigated by application of GBCA. The mean objective is to understand the changes in inflamed tissue and correlate alterations of the BBB by LA-ICP-MS (Imaging Mass Cytometry)." @default.
- W2998532192 created "2020-01-10" @default.
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- W2998532192 date "2019-01-01" @default.
- W2998532192 modified "2023-09-23" @default.
- W2998532192 title "Imaging mass cytometry for visualisation of neuroinflammation induced changes" @default.
- W2998532192 hasPublicationYear "2019" @default.
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