Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998532893> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2998532893 endingPage "vi145" @default.
- W2998532893 startingPage "vi145" @default.
- W2998532893 abstract "Abstract INTRO/OBJECTIVE Glioblastoma (GBM) and MGMT have been reported to have sexual dimorphism. The primary objective of this study was to analyze the impact and association between sex and MGMT status on progression-free survival (PFS) and overall survival (OS) in patients with newly diagnosed GBM. METHODS 582 patients with newly diagnosed GBM who underwent first surgical intervention at a single tertiary care institution between 2012 and 2018 were reviewed. Adults with documented methylated (≥ 12) and un-methylated (≤ 7) MGMT status were included. A Kaplan-Meier and Cox proportional hazard models were used to analyze the association between sex and MGMT status on PFS and OS. RESULTS 464 adult patients (median age 63.4, 36.6% female) had documented MGMT status. Overall rate of MGMT methylated patients was 42.5%, while females were more often methylated than males (52.1% vs 37.4%, p=0.004). MGMT methylated compared to un-methylated females (median: 12.8 vs 7.4 months; 1-yr: 53% vs 27%) had a greater PFS benefit than males (median: 9.6 vs 6.8 months; 1-yr: 44% vs 23%). OS was significantly improved in MGMT methylated compared to un-methylated patients among females (p=0.001) but not among males (p=0.22). Among MGMT methylated patients, females had significantly better OS compared to males (median: 18.7 vs 12.4 months; 2-yr OS: 36.8% vs 24.3%, p=0.03). Although statistically not significant, a similar pattern was observed on PFS (median: 12.8 vs 9.6 months; 1-yr PFS: 52.6% vs 44.4%). Compared to MGMT methylated females, MGMT methylated males had a PFS HR=1.22 (95% CI=0.80 – 1.85, p=0.36), and an OS HR=1.45 (95% CI=1.03 – 2.04, p=0.032). CONCLUSION MGMT methylation is more common in females and methylation had a larger impact on both PFS and OS in females compared to males. These analyses highlight the need to further investigate sex differences that can inform clinical management of GBM." @default.
- W2998532893 created "2020-01-10" @default.
- W2998532893 creator A5004589257 @default.
- W2998532893 creator A5014068004 @default.
- W2998532893 creator A5016811839 @default.
- W2998532893 creator A5021893710 @default.
- W2998532893 creator A5025656360 @default.
- W2998532893 creator A5029857725 @default.
- W2998532893 creator A5033599840 @default.
- W2998532893 creator A5035416012 @default.
- W2998532893 creator A5039022235 @default.
- W2998532893 creator A5039857530 @default.
- W2998532893 creator A5058440874 @default.
- W2998532893 creator A5065263618 @default.
- W2998532893 creator A5069254697 @default.
- W2998532893 creator A5071554403 @default.
- W2998532893 creator A5073914997 @default.
- W2998532893 creator A5075490964 @default.
- W2998532893 creator A5079216912 @default.
- W2998532893 creator A5087295298 @default.
- W2998532893 date "2019-11-01" @default.
- W2998532893 modified "2023-09-24" @default.
- W2998532893 title "PATH-13. SEX-LINKED TUMORAL MGMT STATUS AND OUTCOMES IN NEWLY DIAGNOSED GLIOBLASTOMA" @default.
- W2998532893 doi "https://doi.org/10.1093/neuonc/noz175.609" @default.
- W2998532893 hasPublicationYear "2019" @default.
- W2998532893 type Work @default.
- W2998532893 sameAs 2998532893 @default.
- W2998532893 citedByCount "0" @default.
- W2998532893 crossrefType "journal-article" @default.
- W2998532893 hasAuthorship W2998532893A5004589257 @default.
- W2998532893 hasAuthorship W2998532893A5014068004 @default.
- W2998532893 hasAuthorship W2998532893A5016811839 @default.
- W2998532893 hasAuthorship W2998532893A5021893710 @default.
- W2998532893 hasAuthorship W2998532893A5025656360 @default.
- W2998532893 hasAuthorship W2998532893A5029857725 @default.
- W2998532893 hasAuthorship W2998532893A5033599840 @default.
- W2998532893 hasAuthorship W2998532893A5035416012 @default.
- W2998532893 hasAuthorship W2998532893A5039022235 @default.
- W2998532893 hasAuthorship W2998532893A5039857530 @default.
- W2998532893 hasAuthorship W2998532893A5058440874 @default.
- W2998532893 hasAuthorship W2998532893A5065263618 @default.
- W2998532893 hasAuthorship W2998532893A5069254697 @default.
- W2998532893 hasAuthorship W2998532893A5071554403 @default.
- W2998532893 hasAuthorship W2998532893A5073914997 @default.
- W2998532893 hasAuthorship W2998532893A5075490964 @default.
- W2998532893 hasAuthorship W2998532893A5079216912 @default.
- W2998532893 hasAuthorship W2998532893A5087295298 @default.
- W2998532893 hasBestOaLocation W29985328931 @default.
- W2998532893 hasConcept C126322002 @default.
- W2998532893 hasConcept C143998085 @default.
- W2998532893 hasConcept C207103383 @default.
- W2998532893 hasConcept C2776194525 @default.
- W2998532893 hasConcept C44249647 @default.
- W2998532893 hasConcept C502942594 @default.
- W2998532893 hasConcept C50382708 @default.
- W2998532893 hasConcept C71924100 @default.
- W2998532893 hasConcept C90924648 @default.
- W2998532893 hasConceptScore W2998532893C126322002 @default.
- W2998532893 hasConceptScore W2998532893C143998085 @default.
- W2998532893 hasConceptScore W2998532893C207103383 @default.
- W2998532893 hasConceptScore W2998532893C2776194525 @default.
- W2998532893 hasConceptScore W2998532893C44249647 @default.
- W2998532893 hasConceptScore W2998532893C502942594 @default.
- W2998532893 hasConceptScore W2998532893C50382708 @default.
- W2998532893 hasConceptScore W2998532893C71924100 @default.
- W2998532893 hasConceptScore W2998532893C90924648 @default.
- W2998532893 hasIssue "Supplement_6" @default.
- W2998532893 hasLocation W29985328931 @default.
- W2998532893 hasLocation W29985328932 @default.
- W2998532893 hasOpenAccess W2998532893 @default.
- W2998532893 hasPrimaryLocation W29985328931 @default.
- W2998532893 hasRelatedWork W2120574916 @default.
- W2998532893 hasRelatedWork W2343768426 @default.
- W2998532893 hasRelatedWork W2558534037 @default.
- W2998532893 hasRelatedWork W2568900248 @default.
- W2998532893 hasRelatedWork W281212327 @default.
- W2998532893 hasRelatedWork W2969537103 @default.
- W2998532893 hasRelatedWork W3009255790 @default.
- W2998532893 hasRelatedWork W3161418770 @default.
- W2998532893 hasRelatedWork W4281560766 @default.
- W2998532893 hasRelatedWork W4322099846 @default.
- W2998532893 hasVolume "21" @default.
- W2998532893 isParatext "false" @default.
- W2998532893 isRetracted "false" @default.
- W2998532893 magId "2998532893" @default.
- W2998532893 workType "article" @default.