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• W2998537488 abstract "Background: Coumarin and thiazole derivatives have been used traditionally for many centuries. Because they have anti-tumor, antioxidant activities, and induced apoptosis.&#x0D; Aim: The present study aims to investigate the in vivo antitumor, and antioxidant activities of potassium salt of 5-(4 -chlorophenyl)-2-[(7-hydroxy coumarin-3-ylethylidene) acetyl hydrazine]-1,3 thiazole (5a) and 5-(4 -chlorophenyl)-2-[(8-hydroxy coumarin-3-ylethylidene) acetyl hydrazine]-1,3 thiazole (5b). &#x0D; Materials and Methods: Toxicity has been determined for the synthesized compound. Anti-cancer and anti-oxidant activities were studied through the evaluation of tumor cell viability, lifespan prolongation and antioxidant estimation.&#x0D; Results: Doses of up to 500 mg/kg showed good protection in 5a and 5b compounds. Results of in vivo anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells for the compounds studied showed a significant reduction in the volume and number of ascites. And increased in life span. In therapeutic and preventive groups, compounds 5a and 5b have anti-oxidant properties by a significant decrease in malondialdehyde and significant increased catalase and GSH. Also, compounds 5a and 5b induced apoptosis by increase Caspase-3 and BCL-2 associated protein (BAX), Compared to the group of positive controls.&#x0D; Conclusion: It was concluded that compounds 5a and 5b have a potent antitumor and antioxidant activity against Ehrlich ascites carcinoma in mice." @default.
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• W2998537488 date "2019-12-26" @default.
• W2998537488 modified "2023-09-23" @default.
• W2998537488 title "In vivo Biochemical Evaluation of Some Synthesize Thiazole Derivatives Containing Coumarin Moiety as Antioxidant and Antitumor Agents" @default.
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• W2998537488 doi "https://doi.org/10.9734/ajrb/2019/v5i430104" @default.
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