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- W2998537925 abstract "Movement of chromosome sites within interphase cells is critical for numerous pathways including RNA transcription and genome organization. Yet, a mechanism for reorganizing chromatin in response to these events had not been reported. Here, we delineate a molecular chaperone-dependent pathway for relocating activated gene loci in yeast. Our presented data support a model in which a two-authentication system mobilizes a gene promoter through a dynamic network of polymeric nuclear actin. Transcription factor-dependent nucleation of a myosin motor propels the gene locus through the actin matrix, and fidelity of the actin association was ensured by ARP-containing chromatin remodelers. Motor activity of nuclear myosin was dependent on the Hsp90 chaperone. Hsp90 further contributed by biasing the remodeler-actin interaction toward nucleosomes with the non-canonical histone H2A.Z, thereby focusing the pathway on select sites such as transcriptionally active genes. Together, the system provides a rapid and effective means to broadly yet selectively mobilize chromatin sites." @default.
- W2998537925 created "2020-01-10" @default.
- W2998537925 creator A5035490948 @default.
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- W2998537925 creator A5070335220 @default.
- W2998537925 creator A5085397028 @default.
- W2998537925 creator A5090268068 @default.
- W2998537925 date "2020-02-01" @default.
- W2998537925 modified "2023-10-16" @default.
- W2998537925 title "Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation" @default.
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