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- W2998575741 abstract "Background: Herbal medications, due to their various biologically active components and less toxic profile,have been popular amongst researchers since decades. One good example is Linum usitatissimum (Lu)commonly known as Flaxseeds. The aim of present study was to assess the anti hyperglycemic and antidyslipidemic activities of ethanolic extract of flax seeds (Linum usitatissimum) in streptozotocin induceddiabetic rat model.Methods: The ethanolic extract of flax seeds (Linum usitatissimum) at a dose of 200 mg/kg and 400mg/kgwere given to the streptozotocin-induced diabetic rats for the period of 28 days. FBS, insulin, HbA1c, lipidprofile and serum amylase were evaluated and were compared with positive and negative controls andstandard drugs like Glimepiride 0.1 mg/kg b.w., Metformin 10mg/kg b.w. and Rosuvastatin 10mg/kg/dayb.w.Results: Both doses of flax seeds 200 mg/kg and 400 mg/kg (Linum usitatissimum) extracts demonstratedsignificant (p<0.001) decrease in FBS of diabetic rats. Mainly Linum usitatissimum at the dosage of 400 mg/kgb.w. showed good efficacy in declining fasting blood glucose levels which was comparable with standardanti hyperglycemic drugs. Both doses of herbal extracts also showed significant decline in triglycerides, totalcholesterol, and low-density lipoprotein (LDL-C), very low-density lipoproteins (VLDL-C), and serum amylaselevels with prominent improvement in HDL-C levels in diabetic rats compared to positive controls.Conclusion: This study reveals that the flax seeds (Lu) at the dose of both 200mg/kg and 400mg/kg havenoteworthy potential to reduce hyperglycemia and dyslipidemia associated with diabetes, therefore maybe it is useful in the management of Type-2 diabetes mellitus." @default.
- W2998575741 created "2020-01-10" @default.
- W2998575741 creator A5038252048 @default.
- W2998575741 date "2019-10-30" @default.
- W2998575741 modified "2023-09-24" @default.
- W2998575741 title "ANTI HYPERGLYCEMIC AND ANTI DYSLIPIDEMIC EFFECTS OF FLAX SEEDS (LINUM USITATISSIMUM) EXTRACT IN DIABETIC RATS MODEL" @default.
- W2998575741 hasPublicationYear "2019" @default.
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