Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998577239> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2998577239 endingPage "823" @default.
- W2998577239 startingPage "809" @default.
- W2998577239 abstract "Spinal α-motoneurons directly innervate skeletal muscles and function as the final common path for movement and behavior. The processes that determine the excitability of motoneurons are critical for the execution of motor behavior. In fact, it has been noted that spinal motoneurons receive various neuromodulatory inputs, especially monoaminergic one. However, the roles of histamine and hypothalamic histaminergic innervation on spinal motoneurons and the underlying ionic mechanisms are still largely unknown. In the present study, by using the method of intracellular recording on rat spinal slices, we found that activation of either H1 or H2 receptor potentiated repetitive firing behavior and increased the excitability of spinal α-motoneurons. Both of blockage of K+ channels and activation of Na+-Ca2+ exchangers were involved in the H1 receptor-mediated excitation on spinal motoneurons, whereas the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels were responsible for the H2 receptor-mediated excitation. The results suggest that, through switching functional status of ion channels and exchangers coupled to histamine receptors, histamine effectively biases the excitability of the spinal α-motoneurons. In this way, the hypothalamospinal histaminergic innervation may directly modulate final motor outputs and actively regulate spinal motor reflexes and motor execution." @default.
- W2998577239 created "2020-01-10" @default.
- W2998577239 creator A5005835667 @default.
- W2998577239 creator A5005838892 @default.
- W2998577239 creator A5037775654 @default.
- W2998577239 creator A5057301071 @default.
- W2998577239 creator A5074622046 @default.
- W2998577239 creator A5088412292 @default.
- W2998577239 date "2019-12-25" @default.
- W2998577239 modified "2023-10-03" @default.
- W2998577239 title "Facilitation of spinal α-motoneuron excitability by histamine and the underlying ionic mechanisms." @default.
- W2998577239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31879736" @default.
- W2998577239 hasPublicationYear "2019" @default.
- W2998577239 type Work @default.
- W2998577239 sameAs 2998577239 @default.
- W2998577239 citedByCount "2" @default.
- W2998577239 countsByYear W29985772392020 @default.
- W2998577239 countsByYear W29985772392023 @default.
- W2998577239 crossrefType "journal-article" @default.
- W2998577239 hasAuthorship W2998577239A5005835667 @default.
- W2998577239 hasAuthorship W2998577239A5005838892 @default.
- W2998577239 hasAuthorship W2998577239A5037775654 @default.
- W2998577239 hasAuthorship W2998577239A5057301071 @default.
- W2998577239 hasAuthorship W2998577239A5074622046 @default.
- W2998577239 hasAuthorship W2998577239A5088412292 @default.
- W2998577239 hasConcept C169760540 @default.
- W2998577239 hasConcept C170493617 @default.
- W2998577239 hasConcept C185592680 @default.
- W2998577239 hasConcept C2776752467 @default.
- W2998577239 hasConcept C2778501154 @default.
- W2998577239 hasConcept C2780775167 @default.
- W2998577239 hasConcept C55493867 @default.
- W2998577239 hasConcept C86803240 @default.
- W2998577239 hasConceptScore W2998577239C169760540 @default.
- W2998577239 hasConceptScore W2998577239C170493617 @default.
- W2998577239 hasConceptScore W2998577239C185592680 @default.
- W2998577239 hasConceptScore W2998577239C2776752467 @default.
- W2998577239 hasConceptScore W2998577239C2778501154 @default.
- W2998577239 hasConceptScore W2998577239C2780775167 @default.
- W2998577239 hasConceptScore W2998577239C55493867 @default.
- W2998577239 hasConceptScore W2998577239C86803240 @default.
- W2998577239 hasIssue "6" @default.
- W2998577239 hasLocation W29985772391 @default.
- W2998577239 hasOpenAccess W2998577239 @default.
- W2998577239 hasPrimaryLocation W29985772391 @default.
- W2998577239 hasRelatedWork W1579021682 @default.
- W2998577239 hasRelatedWork W1940779870 @default.
- W2998577239 hasRelatedWork W2000850478 @default.
- W2998577239 hasRelatedWork W2093548853 @default.
- W2998577239 hasRelatedWork W2157407586 @default.
- W2998577239 hasRelatedWork W2255472327 @default.
- W2998577239 hasRelatedWork W2998577239 @default.
- W2998577239 hasRelatedWork W3006836401 @default.
- W2998577239 hasRelatedWork W3130700305 @default.
- W2998577239 hasRelatedWork W4225853715 @default.
- W2998577239 hasVolume "71" @default.
- W2998577239 isParatext "false" @default.
- W2998577239 isRetracted "false" @default.
- W2998577239 magId "2998577239" @default.
- W2998577239 workType "article" @default.