FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998582467> ?p ?o ?g. }

• W2998582467 abstract "Excessive and persistent inflammation after injury lead to chronic wounds, increased tissue damage or even aggressive carcinogenic transformation. Effective wound repair could be achieved by inhibiting overactive immune cells to the injured site. In this study, we obtained high concentration of PD-L1 in exosomes from either genetically engineered cells overexpressing PD-L1 or IFN-γ stimulated cells. We found that exosomal PD-L1 is specially bound to PD-1 on T cell surface, and suppressed T cell activation. Interestingly, exosomal PD-L1 promoted the migration of epidermal cells and dermal fibroblasts when pre-incubated with T cells. We further embedded exosomes into thermoresponsive PF-127 hydrogel, which was gelatinized at body temperature to release exosomes to the surroundings in a sustained manner. Of importance, in a mouse skin excisional wound model, exosomal PD-L1 significantly fastened wound contraction and reepithelialization when embedded in hydrogel during inflammation phase. Finally, exosomal PD-L1 inhibited cytokine production of CD8+ T cells and suppressed CD8+ T cell numbers in spleen and peripheral lymph nodes. Taken together, these data provide evidence on exosomal PD-L1 exerting immune inhibitory effects and promoting tissue repair." @default.
• W2998582467 created "2020-01-10" @default.
• W2998582467 creator A5004349988 @default.
• W2998582467 creator A5006338780 @default.
• W2998582467 creator A5012706476 @default.
• W2998582467 creator A5014058012 @default.
• W2998582467 creator A5017383224 @default.
• W2998582467 creator A5028141611 @default.
• W2998582467 creator A5029424879 @default.
• W2998582467 creator A5030530349 @default.
• W2998582467 creator A5034395409 @default.
• W2998582467 creator A5034816956 @default.
• W2998582467 creator A5035567894 @default.
• W2998582467 creator A5038309864 @default.
• W2998582467 creator A5040153842 @default.
• W2998582467 creator A5048888132 @default.
• W2998582467 creator A5069138081 @default.
• W2998582467 date "2019-12-27" @default.
• W2998582467 modified "2023-10-13" @default.
• W2998582467 title "Exosomal PD‐L1 functions as an immunosuppressant to promote wound healing" @default.
• W2998582467 cites W1608217646 @default.
• W2998582467 cites W1856206988 @default.
• W2998582467 cites W1877686344 @default.
• W2998582467 cites W1967162280 @default.
• W2998582467 cites W1997731331 @default.
• W2998582467 cites W2014411198 @default.
• W2998582467 cites W2015387324 @default.
• W2998582467 cites W2021009347 @default.
• W2998582467 cites W2030106234 @default.
• W2998582467 cites W2039147606 @default.
• W2998582467 cites W2080418767 @default.
• W2998582467 cites W2085293124 @default.
• W2998582467 cites W2102010912 @default.
• W2998582467 cites W2108933323 @default.
• W2998582467 cites W2125366323 @default.
• W2998582467 cites W2127903487 @default.
• W2998582467 cites W2136731993 @default.
• W2998582467 cites W2143729276 @default.
• W2998582467 cites W2144601357 @default.
• W2998582467 cites W2252568502 @default.
• W2998582467 cites W2292821496 @default.
• W2998582467 cites W2296538017 @default.
• W2998582467 cites W2299393419 @default.
• W2998582467 cites W2326555481 @default.
• W2998582467 cites W2403293254 @default.
• W2998582467 cites W2547310148 @default.
• W2998582467 cites W2572174216 @default.
• W2998582467 cites W2598910330 @default.
• W2998582467 cites W2621934018 @default.
• W2998582467 cites W2767343890 @default.
• W2998582467 cites W2772391116 @default.
• W2998582467 cites W2779658193 @default.
• W2998582467 cites W2793992337 @default.
• W2998582467 cites W2809724091 @default.
• W2998582467 cites W2887249435 @default.
• W2998582467 cites W2890207167 @default.
• W2998582467 cites W2902282736 @default.
• W2998582467 cites W2934922729 @default.
• W2998582467 cites W2967085079 @default.
• W2998582467 doi "https://doi.org/10.1080/20013078.2019.1709262" @default.
• W2998582467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7580831" @default.
• W2998582467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33133428" @default.
• W2998582467 hasPublicationYear "2019" @default.
• W2998582467 type Work @default.
• W2998582467 sameAs 2998582467 @default.
• W2998582467 citedByCount "56" @default.
• W2998582467 countsByYear W29985824672021 @default.
• W2998582467 countsByYear W29985824672022 @default.
• W2998582467 countsByYear W29985824672023 @default.
• W2998582467 crossrefType "journal-article" @default.
• W2998582467 hasAuthorship W2998582467A5004349988 @default.
• W2998582467 hasAuthorship W2998582467A5006338780 @default.
• W2998582467 hasAuthorship W2998582467A5012706476 @default.
• W2998582467 hasAuthorship W2998582467A5014058012 @default.
• W2998582467 hasAuthorship W2998582467A5017383224 @default.
• W2998582467 hasAuthorship W2998582467A5028141611 @default.
• W2998582467 hasAuthorship W2998582467A5029424879 @default.
• W2998582467 hasAuthorship W2998582467A5030530349 @default.
• W2998582467 hasAuthorship W2998582467A5034395409 @default.
• W2998582467 hasAuthorship W2998582467A5034816956 @default.
• W2998582467 hasAuthorship W2998582467A5035567894 @default.
• W2998582467 hasAuthorship W2998582467A5038309864 @default.
• W2998582467 hasAuthorship W2998582467A5040153842 @default.
• W2998582467 hasAuthorship W2998582467A5048888132 @default.
• W2998582467 hasAuthorship W2998582467A5069138081 @default.
• W2998582467 hasBestOaLocation W29985824671 @default.
• W2998582467 hasConcept C104317684 @default.
• W2998582467 hasConcept C145059251 @default.
• W2998582467 hasConcept C167672396 @default.
• W2998582467 hasConcept C185592680 @default.
• W2998582467 hasConcept C203014093 @default.
• W2998582467 hasConcept C20518536 @default.
• W2998582467 hasConcept C2776090121 @default.
• W2998582467 hasConcept C2776914184 @default.
• W2998582467 hasConcept C2780269544 @default.
• W2998582467 hasConcept C2781261824 @default.
• W2998582467 hasConcept C502942594 @default.
• W2998582467 hasConcept C55493867 @default.
• W2998582467 hasConcept C71924100 @default.
• W2998582467 hasConcept C86803240 @default.

• next