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• W2998602015 abstract "An autorhythmic population of excitatory neurons in the brainstem pre-Bötzinger complex is a critical component of the mammalian respiratory oscillator. Two intrinsic neuronal biophysical mechanisms—a persistent sodium current (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mrow><mml:mi>I</mml:mi></mml:mrow><mml:mrow><mml:mi>N</mml:mi><mml:mi>a</mml:mi><mml:mi>P</mml:mi></mml:mrow></mml:msub></mml:math>) and a calcium-activated non-selective cationic current (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mrow><mml:mi>I</mml:mi></mml:mrow><mml:mrow><mml:mi>C</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi></mml:mrow></mml:msub></mml:math>)—were proposed to individually or in combination generate cellular- and circuit-level oscillations, but their roles are debated without resolution. We re-examined these roles in a model of a synaptically connected population of excitatory neurons with <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mrow><mml:mi>I</mml:mi></mml:mrow><mml:mrow><mml:mi>C</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi></mml:mrow></mml:msub></mml:math> and <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mrow><mml:mi>I</mml:mi></mml:mrow><mml:mrow><mml:mi>N</mml:mi><mml:mi>a</mml:mi><mml:mi>P</mml:mi></mml:mrow></mml:msub></mml:math>. This model robustly reproduces experimental data showing that rhythm generation can be independent of <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mrow><mml:mi>I</mml:mi></mml:mrow><mml:mrow><mml:mi>C</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi></mml:mrow></mml:msub></mml:math> activation, which determines population activity amplitude. This occurs when <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mrow><mml:mi>I</mml:mi></mml:mrow><mml:mrow><mml:mi>C</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi></mml:mrow></mml:msub></mml:math> is primarily activated by neuronal calcium fluxes driven by synaptic mechanisms. Rhythm depends critically on <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mrow><mml:mi>I</mml:mi></mml:mrow><mml:mrow><mml:mi>N</mml:mi><mml:mi>a</mml:mi><mml:mi>P</mml:mi></mml:mrow></mml:msub></mml:math> in a subpopulation forming the rhythmogenic kernel. The model explains how the rhythm and amplitude of respiratory oscillations involve distinct biophysical mechanisms." @default.
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• W2998602015 date "2019-03-25" @default.
• W2998602015 modified "2023-10-09" @default.
• W2998602015 title "Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model" @default.
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• W2998602015 doi "https://doi.org/10.7554/elife.41555" @default.
• W2998602015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6433470" @default.
• W2998602015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30907727" @default.
• W2998602015 hasPublicationYear "2019" @default.
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