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- W2998678190 abstract "Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results demonstrate that miR551b-3p translocates to the nucleus with the aid of importin-8 (IPO8) and activates STAT3 transcription. As a consequence, miR551b upregulates the expression of oncostatin M receptor (OSMR) and interleukin-31 receptor-α (IL-31RA) as well as their ligands OSM and IL-31 through STAT3 transcription. We defined this set of genes induced by miR551b-3p as the “oncostatin signaling module,” which provides oncogenic addictions in cancer cells. Notably, OSM is highly expressed in TNBC, and the elevated expression of OSM associates with poor outcome in estrogen-receptor-negative breast cancer patients. Conversely, targeting miR551b with anti-miR551b-3p reduced the expression of the OSM signaling module and reduced tumor growth, as well as migration and invasion of breast cancer cells." @default.
- W2998678190 created "2020-01-10" @default.
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- W2998678190 date "2019-12-01" @default.
- W2998678190 modified "2023-10-18" @default.
- W2998678190 title "miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer" @default.
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- W2998678190 doi "https://doi.org/10.1016/j.celrep.2019.11.085" @default.
- W2998678190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7380555" @default.
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