FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998702928> ?p ?o ?g. }

• W2998702928 endingPage "379" @default.
• W2998702928 startingPage "365" @default.
• W2998702928 abstract "Abstract Human organic cation transporter 1 (hOCT1) and human organic cation transporter 3 (hOCT3) are highly expressed in hepatocytes and play important roles in cationic drug absorption, distribution, and elimination. A previous study demonstrated that downregulation of hOCT1 and hOCT3 mRNA was related to hepatocellular carcinoma (HepG2) prognosis and severity. Whether these transporters expressed in HepG2 cells serve for cationic drug delivery has not been investigated. Besides radioactive transport, options for assessing hOCTs in hepatocytes are limited. This study clarified the significant roles of hOCTs in HepG2 by comparing cationic fluorescent 4‐(4‐(dimethylamino)styryl)‐ N ‐methylpyridinium (ASP + ) with traditional [ 3 H]‐1‐methyl‐4‐phenylpyridinium (MPP + ). The results showed ASP + was preferably transported into HepG2 compared to [ 3 H]‐MPP + with high affinity and a high maximal transport rate. Selective transport of ASP + mediated by hOCTs was influenced by extracellular pH, temperature, and membrane depolarization, corresponding to hOCT1 and hOCT3 expressions. Furthermore, transport of cationic drugs, metformin, and paclitaxel in HepG2 cells was blunted by OCT inhibitors, suggesting that hOCT1 and hOCT3 expressed in HepG2 cells exhibit notable impacts on cationic drug actions. The fluorescent ASP + ‐based in vitro model may also provide a rapid and powerful analytical tool for further screening of cationic drug actions and interactions with hOCTs, particularly hOCT1 and hOCT3 in hepatocellular carcinoma." @default.
• W2998702928 created "2020-01-10" @default.
• W2998702928 creator A5003031716 @default.
• W2998702928 creator A5003201827 @default.
• W2998702928 creator A5004876118 @default.
• W2998702928 creator A5014472034 @default.
• W2998702928 creator A5033533107 @default.
• W2998702928 creator A5063931126 @default.
• W2998702928 creator A5081454564 @default.
• W2998702928 date "2020-02-03" @default.
• W2998702928 modified "2023-09-27" @default.
• W2998702928 title "High affinity of 4‐(4‐(dimethylamino)styryl)‐<i>N</i>‐methylpyridinium transport for assessing organic cation drugs in hepatocellular carcinoma cells" @default.
• W2998702928 cites W1493374490 @default.
• W2998702928 cites W1965064051 @default.
• W2998702928 cites W1970359870 @default.
• W2998702928 cites W1977244805 @default.
• W2998702928 cites W1983241145 @default.
• W2998702928 cites W1983657337 @default.
• W2998702928 cites W1988480204 @default.
• W2998702928 cites W1989980062 @default.
• W2998702928 cites W1992304595 @default.
• W2998702928 cites W1998206026 @default.
• W2998702928 cites W2003534761 @default.
• W2998702928 cites W2025894603 @default.
• W2998702928 cites W2027579967 @default.
• W2998702928 cites W2028921444 @default.
• W2998702928 cites W2033898664 @default.
• W2998702928 cites W2034886511 @default.
• W2998702928 cites W2042871909 @default.
• W2998702928 cites W2043624792 @default.
• W2998702928 cites W2047944613 @default.
• W2998702928 cites W2062764228 @default.
• W2998702928 cites W2065307731 @default.
• W2998702928 cites W2068169313 @default.
• W2998702928 cites W2073858365 @default.
• W2998702928 cites W2075995159 @default.
• W2998702928 cites W2081015465 @default.
• W2998702928 cites W2082967482 @default.
• W2998702928 cites W2093833901 @default.
• W2998702928 cites W2096758996 @default.
• W2998702928 cites W2106189131 @default.
• W2998702928 cites W2108203538 @default.
• W2998702928 cites W2125788269 @default.
• W2998702928 cites W2131582481 @default.
• W2998702928 cites W2138234756 @default.
• W2998702928 cites W2143409207 @default.
• W2998702928 cites W2143926676 @default.
• W2998702928 cites W2144280397 @default.
• W2998702928 cites W2147787974 @default.
• W2998702928 cites W2148672071 @default.
• W2998702928 cites W2150254577 @default.
• W2998702928 cites W2156244027 @default.
• W2998702928 cites W2157492397 @default.
• W2998702928 cites W2157721092 @default.
• W2998702928 cites W2163601154 @default.
• W2998702928 cites W2235836043 @default.
• W2998702928 cites W2252241287 @default.
• W2998702928 cites W2282086193 @default.
• W2998702928 cites W2563456731 @default.
• W2998702928 cites W2589247606 @default.
• W2998702928 cites W2770007752 @default.
• W2998702928 cites W2903715092 @default.
• W2998702928 cites W2910307834 @default.
• W2998702928 cites W2030438100 @default.
• W2998702928 doi "https://doi.org/10.1111/fcp.12531" @default.
• W2998702928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31883148" @default.
• W2998702928 hasPublicationYear "2020" @default.
• W2998702928 type Work @default.
• W2998702928 sameAs 2998702928 @default.
• W2998702928 citedByCount "2" @default.
• W2998702928 countsByYear W29987029282022 @default.
• W2998702928 countsByYear W29987029282023 @default.
• W2998702928 crossrefType "journal-article" @default.
• W2998702928 hasAuthorship W2998702928A5003031716 @default.
• W2998702928 hasAuthorship W2998702928A5003201827 @default.
• W2998702928 hasAuthorship W2998702928A5004876118 @default.
• W2998702928 hasAuthorship W2998702928A5014472034 @default.
• W2998702928 hasAuthorship W2998702928A5033533107 @default.
• W2998702928 hasAuthorship W2998702928A5063931126 @default.
• W2998702928 hasAuthorship W2998702928A5081454564 @default.
• W2998702928 hasConcept C104317684 @default.
• W2998702928 hasConcept C121608353 @default.
• W2998702928 hasConcept C123584848 @default.
• W2998702928 hasConcept C12554922 @default.
• W2998702928 hasConcept C126322002 @default.
• W2998702928 hasConcept C127561419 @default.
• W2998702928 hasConcept C149011108 @default.
• W2998702928 hasConcept C178790620 @default.
• W2998702928 hasConcept C183882617 @default.
• W2998702928 hasConcept C185592680 @default.
• W2998702928 hasConcept C189613389 @default.
• W2998702928 hasConcept C202751555 @default.
• W2998702928 hasConcept C2777292972 @default.
• W2998702928 hasConcept C2778019345 @default.
• W2998702928 hasConcept C2780035454 @default.
• W2998702928 hasConcept C28406088 @default.
• W2998702928 hasConcept C502942594 @default.
• W2998702928 hasConcept C55493867 @default.

• next